20 500例恶性肿瘤患者贫血情况分析

裴王伟 姜慧芬 范润萍 陈勇毅 徐笑红

[摘要]目的 分析20 500例恶性肿瘤患者的贫血情况。方法 回顾性分析2018年1～11月浙江省肿瘤医院收治的20 500例恶性肿瘤患者临床资料，计算不同肿瘤相关性贫血（CRA）的发生率;分析不同CRA的严重程度;分析CRA的年龄分布和性别分布。结果 20 500例CRA发生率为23.7%，CRA发生率最高的为妇科肿瘤，其次为消化和泌尿系统肿瘤，头颈部肿瘤伴发贫血的发生率最低。CRA严重程度多数为1～2级[4424例（91.1%）]，3～4级CRA 434例（8.9%）。CRA的患者年龄多分布在50～<70岁，占60.07%，30～<50岁次之，占20.87%，<30岁最少，占1.26%。男性的CRA发生率高于女性，差异有统计学意义（P<0.05）。结论 CRA整体发生率较高，以1～2级贫血为主，男性CRA发生率高于女性。

[关键词]恶性肿瘤;贫血;肿瘤相关性贫血;血红蛋白

[中图分类号] R73-31          [文献标识码] A          [文章编号] 1674-4721（2020）2（c）-0180-03

Analysis of anemia in 20 500 patients with malignant tumors

PEI Wang-wei   JIANG Hui-fen   FAN Run-ping   CHEN Yong-yi   XU Xiao-hong▲

Department of Clinical Laboratory， Zhejiang Cancer Hospital， Hangzhou   310022， China

[Abstract] Objective To analyze the anemia of 20 500 patients with malignant tumor. Methods The clinical data of 20 500 patients with malignant tumors admitted to Zhejiang cancer hospital from January to November 2018 were analyzed retrospectively， the incidence of different tumor associated anemia （CRA） was calculated. The severity of different CRA were analyzed. The age distribution and gender distribution of CRA were analyzed. Results The incidence of CRA in 20，500 cases was 23.7%. The highest incidence of CRA was gynecological tumors， followed by digestive and urinary system tumors. The incidence of head and neck tumors with anemia was the lowest. The severity of CRA was mostly 4，424 （91.1%） in grades 1-2， and 434 （8.9%） of CRA in grades 3-4. The age of CRA patients were mostly distributed from 50 to <70 years， accounting for 60.07%， followed by 30 to <50 years， accounting for 20.87%， and the youngest were less than 30 years， accounting for 1.26%. The incidence of CRA was higher in men than in women， the difference was statistically significant （P<0.05）. Conclusion The overall incidence of CRA is high， with grade 1-2 anemia as the predominant factor， the incidence of CRA is higher in men than in women.

[Key words] Malignant tumor; Anemia; Cancer related anemia; Hemoglobin

腫瘤相关性贫血（cancer related anemia，CRA）是肿瘤患者本身或者治疗过程中发生的贫血，是恶性肿瘤常见的并发症之一。CRA的发生机制至今还未明确，可能与肿瘤本身、并发症以及治疗引起的骨髓抑制有关[1]。欧洲癌症贫血调查（ECAS）对15 367例肿瘤患者进行了研究，发现64.5%的患者发生贫血[2]。CRA能显著影响肿瘤的临床治疗效果和患者的生存期[3]，是影响肿瘤患者化疗效果及生存率的独立预后因素[4]。ECAS也提到，CRA与患者年龄、性别以及肿瘤类型等多种因素有关[5]。本研究对我院收治的20 500例恶性肿瘤患者资料进行回顾性分析，了解患者的贫血情况，现报道如下。

1资料与方法

1.1一般资料