消瘤止痛膏联合唑来膦酸治疗恶性肿瘤骨转移引起疼痛的疗效分析

徐阳 徐丹

[摘要] 目的 观察消瘤止痛膏联合唑来膦酸治疗恶性肿瘤骨转移引起疼痛的临床疗效。 方法 将恶性肿瘤骨转移引起疼痛的50例患者随机分为两组，即消瘤止痛膏联合唑来膦酸治疗组（联合组）23例与单纯唑来膦酸治疗组（单用组）27例，比较两组的止痛总有效率和患者生活质量和体力状况改善情况。 结果 联合组止痛总有效率为91.3%，单用组为63.0%，两组比较差异有统计学意义（P < 0.05）；患者生活质量和体力状况改善情况联合组优于单用组，两组均无明显不良反应。 结论 消瘤止痛膏联合唑来膦酸治疗恶性肿瘤骨转移引起疼痛的临床效果较满意，具有良好的止痛效果，值得在临床应用。

[关键词] 消瘤止痛膏；唑来膦酸；恶性肿瘤；骨转移

[中图分类号] R73[文献标识码] A[文章编号] 1674-4721（2012）07（c）-0148-02

Clinical effect analysis of Xiaoliuzhitonggao combined with zoletronic acid on pain induced by metastatic bone cancer

XU Yang1 XU Dan2▲

1.Department of Medical Oncology, Traditional Chinese Medical Hospital of Dandong City in Liaoning Province, Dandong 118000, China; 2.Institute of Environmental System Biology of Dalian Maritime University, Dalian 116026, China

[Abstract] Objective To observe the clinical effect of combination of Xiaoliuzhitonggao with zoletronic acid on pain induced by metastatic bone cancer. MethodsFifty patients with pain due to metastatic bone cancer were randomly divided into two groups. Twenty three patients were treated with Xiaoliuzhitonggao and zoletronic acid (combined treatment group), while 27 patients were treated with zoletronic acid alone (alone treatment group). The total efficiency of inhibition on pain was compared between the two groups. Life quantity and physical strength of patients were also observed and evaluated. Results The total efficiency of inhibition on pain was 91.3% and 63.0% in combined treatment group and alone treatment group respectively. There was statistical significance between the two groups (P < 0.05). Life quantity and physical strength of patients were found to be obviously improved in combined treatment group, which was better than alone treatment group. In addition, side-effect was not observed in both groups. Conclusion It is satisfied with the clinical effect of combination of Xiaoliuzhitonggao with zoletronic acid on pain induced by metastatic bone cancer. It has a good analgesic effect and is worthy of clinical application.

[Key words] Xiaoliuzhitonggao; Zoletronic acid; Malignance tumor; Bone metastasis

恶性肿瘤骨转移在晚期癌症患者中比较常见，约30%～70％的恶性肿瘤会发生骨转移。其临床表现为进行性剧烈骨痛、脊髓压迫、骨关节活动障碍及病理性骨折。患者常常因剧烈疼痛，长期慢性营养消耗而严重影响生活质量。本院采用多种中药配方研制了消瘤止痛膏，并与唑来膦酸联合使用治疗骨转移引起的疼痛，取得了比较满意的临床疗效，现报道如下：

1 资料与方法

1.1 一般资料

选择恶性肿瘤骨转移疼痛患者50例，均为本科2010年11月～2011年10月住院患者。患者主诉有明显疼痛，原发肿瘤灶均系病理组织学和（或）细胞学检查证实，骨转移灶经X线、CT或MRI、ECT骨扫描等检查确诊，未用或停用化疗或放疗1个月以上，预计生存期3个月以上。随机分为两组：联合组23例，其中，男12例，女11例，年龄34～65岁；肺癌9例，乳腺癌8例，肾癌2例，肠癌4例；采用消瘤止痛膏联合唑来膦酸治疗。单用组27例，其中，男14例，女13例，年龄36～68歲；肺癌11例，乳腺癌9例，肾癌4例，肠癌3例；……