甲基强的松龙早期短程冲击治疗 小儿重症病毒性脑炎的临床研究

李仕勇

【摘要】目的研究甲基强的松龙早期短程冲击治疗小儿重症病毒性脑炎的临床价值。方法选取本院于2011年6月~2013年6月收治的60例小儿重症病毒性脑炎患者, 将其随机分成观察组和对照组, 各30例；观察组给予大剂量甲基强的松龙冲击治疗；对照组采用地塞米松进行治疗。治疗结束后分析比较两组患者抽搐、发热、脑膜刺激征与意识障碍恢复时间。结果观察组患者症状与体征的恢复正常时间显著比对照组缩短, 两组结果比较差异具有统计学意义(P<0.01)。结论甲基强的松龙早期短程冲击治疗小儿重症病毒性脑炎可以快速改善患者症状, 疗效确切, 缩短治疗时间, 后遗症较少, 治愈率较高, 值得临床推广与应用。

【关键词】甲基强的松龙；冲击治疗；小儿病毒性脑炎

Clinical study on early methylprednisolone pulse therapy in the treatment of children with severe viral encephalitis LI Shi-yong. Yangchun Maternal and Child Health Care, Yangchun 529600, China

【Abstract】 Objective To study the clinical value of early methylprednisolone pulse therapy in the treatment of children with severe viral encephalitis. Methods There were 30 cases of pediatric patients with severe viral encephalitis treated in our hospital from June 2011 to June 2013 who were randomly divided into observation group and control group, 15 cases for each group; observation group were given large doses of methylprednisolone pulse therapy; control group were treated with dexamethasone. After treatment, patients were analyzed and compared the recovery time, convulsions, fever, meningeal irritation and unconsciousness. Results The normal schedule in patients with symptoms and signs of the observation group was significantly shorter than control group, the results of the two groups were statistically significant difference (P<0.01). Conclusion Early methylprednisolone pulse therapy in children with severe short viral encephalitis can quickly improve symptoms, efficacy, with shorten treatment time, fewer complications, a higher cure rate, so it is worthy of promotion and application.

【Key words】 Methylprednisolone; Pulse therapy; Children with viral encephalitis病毒性脑炎是儿童一种较为常见的神经系统疾病, 由于病毒感染导致的脑实质炎症, 通常会造成神经细胞水肿、炎症甚至坏死等症状。轻症患者可以自行改善, 重症患者出现急进性过程, 会有后遗症甚至危及生命, 给儿童的生命健康带来严重的影响［1］。本院于2011年6月~2013年6月应用甲基强的松龙早期短程冲击疗法治疗小儿重症病毒性脑炎并与地塞米松疗法进行分析比较, 现报告如下。

1资料与方法

1. 1一般资料选取本院于2011年6月~2013年6月收治的60例小儿重症病毒性脑炎患儿, 随机分成观察组30例与对照组30例, 观察组男16例, 女14例；年龄2~11岁, 平均年龄(5.7±1.2)岁；对照组男12例, 女18例；年龄2~13岁, 平均年龄(5.8±1.0)岁。纳入标准：参照《实用儿科学》(第6 版)病毒性脑炎诊断标准。瘫痪；持续惊厥或者频繁抽搐；有脑干受累症状：比如血压出现波动、呼吸节律不稳定等；昏迷或者中度昏迷；通过脑干CT或者MRI表现脑干与(或)脑实质异常密度灶, 且符合以上两项以上条件者判定为重症病毒性脑炎。……