肾康注射液联合用药治疗肾小球肾炎合并急性间质性肾炎的临床研究

童瑜

[摘要] 目的 观察肾康注射液联合用药治疗肾小球肾炎合并急性间质性肾炎的临床效果。 方法 选取我院2011年1月～2014年1月收治的110例肾小球肾炎合并急性间质性肾炎患者，将其随机分为观察组和对照组，每组55例，对照组予以青霉素联合降压药物治疗，观察组在对照组的基础上予以肾康注射液进行治疗，比较两组患者的治疗效果以及肾功能变化。 结果 观察组的治疗有效率为85.45%，对照组为67.27%，组间比较差异有统计学意义（P<0.05）。治疗前两组患者的24h尿蛋白定量、1h尿红细胞排泄率、BUN、SCr等肾功能指标比较差异无统计学意义（P>0.05），治疗后均较治疗前有明显改善，但观察组改善的程度更加明显，组间比较差异有统计学意义（P<0.05）。 结论 肾康注射液联合用药治疗肾小球肾炎合并急性间质性肾炎能明显提高临床疗效、改善患者的肾功能，值得临床上的推广应用。

[关键词] 肾小球肾炎；间质性肾炎；联合用药

[中图分类号] R692.31 [文献标识码] B [文章编号] 2095-0616（2015）11-48-03

[Abstract] Objective To observe the effect of using combination therapy of renal injection to treat glomerular nephritis complicate acute interstitial nephritis. Methods Selected 110 cases of patients with glomerular nephritis complicated acute interstitial nephritis from January 2011 to January 2014，randomly divided them into observation group and control group，55 cases in each group，control group used penicillin combined drug therapy，observation group used renal injection for treatmentin on the basis of the control group，compare the curative effect and change of renal function of two groups. Results The effective rate was 85.45% in observation group， control group was 67.27%， the differences between groups was statistically significant（P<0.05）.24 hours urinary protein quantitative，1 hour urinary excretion rate of red blood cells，BUN，SCr had no significant difference between two groups of patients before treatment（P>0.05），after treatment they were obviously improved compared with before treatment，but the extent of improving was more obvious in the observation group，the difference between groups was statistically significant （P<0.05）. Conclusion The combination therapy of renal injection to treat glomerular nephritis complicating acute interstitial nephritis can obviously improve the clinical curative effect，improve the patient's kidney function，worthy of clinical popularization and application.

[Key words] Glomerular nephritis；Interstitial nephritis；Combination

肾小球肾炎简称肾炎，在临床上的高发人群是青年以及中年男性。该病的发病过程较为隐匿且缓慢，部分具有前驱感染表现，主要的临床症状有血尿、蛋白尿、少尿、水肿、肾功能损伤等，部分患者还会出现厌食、恶心呕吐、血压升高等并发症。肾小球肾炎常合并急性间质性肾炎，而在临床上急性间质性肾炎经常会被误诊成为肾小球肾炎加重期的表现，错过了最佳的治疗时机，所以要做好肾小球肾炎合并急性间质性肾炎的诊断，并进行针对性的治疗[1-2]。本研究采用肾康注射液联合用药对此合并症进行治疗，取得良好的效果，现报道如下。

1 资料与方法

1.1 一般资料

选择2011年1月～2014年1月收治的110例肾小球肾炎合并急性间质性肾炎患者，将其随机分为观察组和对照组，每组55例。……