呋塞米联合小剂量多巴胺间歇静脉泵入治疗终末期心力衰竭合并利尿剂抵抗的效果分析

魏 坤

【摘  要】目的  分析呋塞米联合小剂量多巴胺间歇静脉泵入治疗终末期心力衰竭合并利尿剂抵抗的临床疗效。方法  挑选在我院进行治疗的终末期心力衰竭合并利尿剂抵抗患者66例，患者的收治时间均在2012年5月～2015年3月期间，将66例终末期心力衰竭合并利尿剂抵抗患者通过电脑随机分成两组，每组各有患者33例，其中一组患者给予抗心力衰竭治疗及呋塞米静脉推注治疗，称为单一组，另一组患者在单一组患者的基础上，给予间歇性多巴胺静脉泵入，称为联合组，在治疗前后对患者的心功能进行分级，评价单一组患者及联合组患者的临床治疗效果，进行比较。结果 联合组患者的临床总有效率明显高于单一组患者，差异存在统计学意义（即P<0.05）。結论  呋塞米联合小剂量多巴胺间歇静脉泵入治疗终末期心力衰竭合并利尿剂抵抗患者，疗效确切，可推广应用。

【关键词】呋塞米;小剂量多巴胺;静脉泵入;终末期心力衰竭;利尿剂抵抗

Abstract Objective Analysis of furosemide in combination with low-dose dopamine indirect intravenous infusion treatment of end-stage heart failure clinical efficacy of the combined diuretic resistance.Methods Selection in our hospital for treatment of end-stage heart failure with diuretics in patients with 66 cases of resistance，patients treated at all times in May 2012 - March 2015 period，66 patients with end-stage heart failure with diuretics in patients with resistance by computer were randomly divided into two groups of 33 patients each，one group of patients given anti-heart failure treatment and furosemide intravenous injection therapy，known as a single group，the other group of patients on the basis of a single group of patients given intermittent dopamine intravenous infusion，called the combined group，in the treatment of cardiac function in patients before and after grading，evaluation of a single group of patients and clinical results combined group of patients were compared.Results The total combined group of patients with clinical efficiency was significantly higher than single patients，statistically significant differences（ie，P <0.05）.Conclusion Furosemide in combination with low-dose dopamine indirect intravenous infusion treatment of end-stage heart failure patients with diuretic resistance merger effective，can be widely applied.

Key words furosemide;low-dose dopamine;intravenous infusion;end-stage heart failure;diuretic resistance

心力衰竭是指心脏的功能发生障碍，无法将静脉回心血完全排出心脏，导致静脉血在心脏淤积，而动脉血灌注不足，进而引发心脏循环障碍【1】。对于终末期心力衰竭患者，其病情已经发展至晚期，伴有利尿剂抵抗，所以在常规利尿剂治疗的情况下，无明显疗效，进而导致患者的预后较差【2】。但利尿剂是控制心力衰竭患者尿潴留的唯一有效药物，正确使用利尿药是改善终末期心力衰竭患者预后的关键。笔者就对本院收治的终末期心力衰竭患者给予呋塞米联合小剂量多巴胺进行间歇静脉泵入治疗，探究其临床治疗效果，内容如下。……