拉萨市区成年人高尿酸血症和痛风的流行病学调查 *

拉萨市区成年人高尿酸血症和痛风的流行病学调查*

杨丽辉1宋嘉1石荔2吕雪梅1阿米娜1杨森淋1巴桑普赤1孟树优1

(西藏自治区人民医院1.内五科，2.感染科， 西藏 拉萨 850000)

【摘要】目的了解西藏拉萨市成年人高尿酸血症(HUA)和痛风的患病率及其影响因素。方法采用随机、整群抽样方法，调查拉萨市区常住居民3 582人HUA及痛风的患病情况。 结果调查的3 582例人群中HUA总患病率为25.80%，标化后的患病率为27.37%。痛风的患病率为9.85%，标化后患病率为10.07%。整体人群血尿酸水平为(380.6±67.3)μmol/L，男性血尿酸水平高于女性，藏族人群血尿酸水平高于汉族人群。HUA组和痛风组年龄、高原居住时间、血压、血糖、血色素及血脂水平均明显高于正常组(P<0.05)。结论拉萨市区成年人群HUA及痛风的患病率高于内地水平，且民族、性别、血糖与血脂间存在明显差异，藏族同胞患病率高于汉族。

【关键词】拉萨市； 高尿酸血症； 痛风； 流行病学

【中图分类号】R 589.7

【文献标志码】A

doi：10.3969/j.issn.1672-3511.2015.10.009

Abstract【】ObjectiveTo understand the prevalence and influencing factors of hyperuricemia (HUA) and gout among adult in Lhasa of Tibet. MethodsThe mordiey rates with HUA or gout among 3 582 healthy people examined in our hospital of 2010 were analyzed. ResultsTotal prevalence rate of HUA was 27.37%. The prevalence rate of gout was 9.85%, and the standardized incidence ratio was 10.07%. The serum uric acid level of overall was (380.6±67.3) μmol/L. The blood uric acid level in male was higher than the female; the Tibetan population was higher than Han population. People with HUA or gout was significantly higher than other people, in the aspects of age, residence time in high altitude area, blood pressure, blood sugar, hemoglobin and blood lipids (P<0.05). ConclusionThe prevalence of HUA and gout among urban population of Lhasa was higher than that of low altitude area.

基金项目：国家自然科学基金(30860243)

通讯作者：宋嘉，E-mail, songjia1108@hotmail.com

收稿日期：( 2015-01-12； 编辑： 陈舟贵)

Epidemiological survey on hyperuricemia and gout among urban population of LhasaYANG Lihui，SONG Jia，SHI Li,etal

(TheFifthDepartmentofInternalMedicine,ThePeople’sHospitalofTibetAutonomousRegion，Lhasa850000,China)

【Key words】Epidemiology; Hyperuricemia; Gout; Lhasa

痛风是一种嘌呤代谢异常和/或体内尿酸浓度持续升高而引起的以关节和肾脏损害为主要表现的代谢性疾病，高尿酸血症是其重要生化特征[1]。由于高原特殊的高海拔环境和相应的饮食结构，加之近几年来高原移居人口增多，在临床工作中发现高尿酸血症和痛风的病人门诊人数日渐增多。通过文献调研发现西藏地区目前还没有系统的HUA及痛风的流行病学调查研究[2]。为此，我们于2010～2014年对拉萨市区常住人群进行了HUA及痛风的流行病学抽样调查，了解本市患病人群的基本发病情况，寻找出可能导致HUA和痛风发病的危险因素，为西藏地区慢病寻求相应措施也可为全区大规模高尿酸血症(HUA)及痛风调查奠定基础。……