益母草注射液联合缩宫素对剖宫产术产后出血的影响

益母草注射液联合缩宫素对剖宫产术产后出血的影响

李淑英，刘雪彩，张彦敏，张桂英，曹素艳

(赞皇县医院，河北 赞皇 051230)

摘要：目的探讨益母草注射液联合缩宫素对剖宫产术产后出血的影响。方法选取行剖宫产分娩的150例产妇为研究对象，随机分为治疗组和对照组，各75例，2组产妇均采用腰-硬联合麻醉下行剖宫产术，对照组采用单纯缩宫素进行治疗，治疗组采用益母草注射液联合缩宫素进行治疗，观察2组产妇术中和术后0～2、2～24、24～48 h出血量，术后1～5 d子宫复旧情况，术前、术后24 h血红蛋白(Hb)及红细胞计数(RBC)，观察2组用药期间不良反应。结果治疗组术中和术后0～2、2～24、24～48 h出血量显著少于对照组(P<0．05)；治疗组术后1～5 d子宫下降高度大于对照组(P<0．05)；治疗组术后24 h Hb、RBC下降程度低于对照组(P<0．05)。结论益母草注射液联合缩宫素能有效减少剖宫产术中、术后出血，降低产后出血的发生率，其起效快、止血效果好、不良反应少。

关键词：缩宫素；益母草注射液；剖宫产术；产后出血

DOI:10.13463/j.cnki.cczyy.2015.06.054

中图分类号：R271.9文献标志码：A

文章编号：2095-6258(2015)06-1243-03

基金项目：河北省科学研究与发展计划项目(2015)。

作者简介：李淑英(1979-)，女，大学本科，主要从事妇产科疾病研究。

收稿日期:(2015-08-27)

Leonurus japonicus injection in combined with oxytocin on postpartum hemorrhage after cesarean section

LI Shuying, LIU Xuecai, ZHANG Yanmin, ZHANG Guiying, CAO Suyan

(Zanhuang Hospital of Hebei Province, Zanhuang 051230, Hebei Province, China)

Abstract：ObjectiveTo explore the effect of leonurus japonicus injection in combined with oxytocin on the postpartum hemorrhage after cesarean section. MethodsA total of 150 puerpera were included in the study and randomized into the observation group and the control group with 75 cases in each group. The puerpera in the two groups were performed with cesarean section under the combined spinal-epidural anesthesia. The patients in the control group were only given oxytocin treatment, while the patients in the observation group were given leonurus japonicus injection in combined with oxytocin. The amount of bleeding during operation, 0-2 h, 2-24 h, 24-48 h after operation, the uterine involution 1-5d after operation, Hb and RBC before operation and 24h after operation, and the adverse reactions during the medication period in the two groups were observed. Resultsmount of bleeding during operation, 0-2 h, 2-24 h, 24-48 h after operation in the observation group was significantly less than that in the control group (P<0.05). The uterine fundus declining height 1-5d after operation in the observation group was significantly greater than that in the control group (P<0.05). Hb and RBC declining degree 24h after operation in the observation group was significantly lower than that in the control group (P<0.05). The occurrence rate of the adverse reactions in the observation group was lower than that in the control group, but the comparison was not statistically significant (P>0.05). ConclusionLeonurus japonicus injection in combined with oxytocin can effectively decrease the amount of bleeding during operation and after operation, and reduce the occurrence rate of postpartum hemorrhage with a rapid and favorable hemostatic effect and less adverse reactions; therefore, it can be served as one of the regimens for preventing postpartum hemorrhage in the clinic.

Keywords：oxytocin; leonurus japonicus injection; cesarean section; postpartum hemorrhage

产后出血是产科最严重的并发症，是导致产妇死亡主要的原因之一，其病因主要为宫缩乏力、软产道撕裂、胎盘因素及凝血功能障碍等，而宫缩乏力最常见，占70%～90%[1-4]，因此防止宫缩乏力成为预防产后出血的关键[5-8]。笔者采用益母草注射液联合缩宫素进行产后预防性治疗，以探讨其对产后出血的影响。现报道如下。

1资料与方法

1．1一般资料选取赞皇县医院2014年4月—2015年4月行剖宫产分娩的150例产妇为研究对象，年龄23～41岁，平均(25．2±3．5)岁；初产妇108例，经产妇42例；孕周37～42周，平均(39．5±1．8)周；手术时间平均(41．5±3．2)min；新生儿体质量平均(3205．2±358．4)g。所有……