中西医结合治疗白塞病口腔溃疡23例临床观察

中西医结合治疗白塞病口腔溃疡23例临床观察

刘路路1邵洪伟2高明利3

1.辽宁中医药大学，辽宁沈阳110032；2.辽宁中医药大学附属第四医院，辽宁沈阳110032；

3.辽宁中医药大学附属医院风湿免疫科，辽宁沈阳110032

【摘要】目的：观察会厌逐瘀汤代茶饮治疗白塞病口腔溃疡的临床疗效。方法：选取确诊为白塞病的患者46例，随机分为治疗组和对照组，对照组予沙利度胺75mg/d，治疗组在对照组基础上加会厌逐瘀汤代茶饮1500ml每日不拘时服，均连续治疗3个月。分别观察并记录治疗前、治疗后3个月期间溃疡间歇时间总和(d)和溃疡复发数目总和(个)。结果：治疗组总有效率95.45%，对照组总有效率66.67%，两组差异具有统计学意义(P<0.05)。结论：会厌逐瘀汤代茶饮联合沙利度胺治疗白塞病口腔溃疡疗效优于单纯应用沙利度胺。

【关键词】白塞病；口腔溃疡；瘀血；会厌逐瘀汤

【中图分类号】R781.5`(+1)

【文献标志码】A

【文章编号】1007-8517(2015)21-0068-03

Abstract:Objective To observe the clinical efficacy of epiglottis Zhuyu Decoction on behalf of the tea by oral ulcer treatment of Behcet's disease.Methods 46 cases of Behcet's disease were randomly divided into treatment group and control group, treatment group was treated with thalidomide plus 75mg/d epiglottis Zhuyu Decoction on behalf of the tea 1500ml daily at any time; control group was treated with thalidomide 75mg/d. Both lasted for 3 months. 3 months before and after treatment were observed and recorded during the sum of ulcer interval time (days) and the total number of (a) the recurrence of peptic ulcer. Results The total effective rate was 95.45% in treatment group and control group in the total efficiency of 66.67%, with significant difference between two groups (P<0.05).Conclusion The epiglottis Zhuyu Decoction on behalf of the tea combined with thalidomide in treatment of oral cavity ulcer curative effect is better than the simple application of thalidomide in Behcet's disease.

Keywords:Behcet's Disease;Oral Ulcer;Blood Stasis;Epiglottis Zhuyu Decoction

收稿日期：(2015.08.10)

The Epiglottis Zhuyu Decoction on behalf of the Tea Treatment of Oral Cavity

Ulcer Curative Effect Observation of Behcet′s Disease

LIU Lulu1SHAO Hongwei2GAO Mingli3

1.Liaoning University of TCM, Shenyang 110032,China; 2.The Fourth Affiliated Hospital of Liaoning University of TCM,Shenyang 110032,China;

3.Department of Rheumatology of the Affiliated Hospital of Liaoning University of TCM,Shenyang 110032,China

白塞病，又称贝赫切特病(Behcet disease,BD)是一种以血管炎为主要病理改变的自身免疫性疾病，临床表现通常以反复发作的口腔溃疡、外阴溃疡、眼炎及皮肤损害为多见，并可累及血管、神经系统、关节、消化道、肺、肾、附睾等器官[1]。目前西医治疗主要以外用药局部治疗、非甾体抗炎药、秋水仙碱、沙利度胺、糖皮质激素、生物制剂等为主[2]。笔者以祖国传统医学理论为基础，从瘀血角度立论分析，以王清任的会厌逐瘀汤为主方，加减治疗22例以复发性口腔溃疡为主要症状的白塞病患者，收效良好，报道如下。

1资料与方法

1.1一般资料选取2013年4月至2014年5月就诊于辽宁省中医院门诊患者46例。按随机数字表法随机分为两组，治疗组23例，其中男10例，女13例，年龄23～54岁，平均年龄(35.82±7.25)岁，病程2～7年，平均病程(3.61±1.48)年；……