小牛血去蛋白提取物眼用凝胶联合吲哚美辛滴眼液治疗持续性角膜上皮缺损疗效观察

作者单位：462002 漯河，漯河医学高等专科学校第三附属医院

小牛血去蛋白提取物眼用凝胶联合吲哚美辛滴眼液治疗持续性角膜上皮缺损疗效观察

冯彩霞张静慧

【摘要】目的探讨小牛血去蛋白提取物眼用凝胶联合吲哚美辛滴眼液治疗持续性角膜上皮缺损(PCED)的临床疗效。方法78例PCED患者 (包括外伤15例、手术16例、化学烧伤23例、角膜炎18例、其它原因6例)随机分成治疗组(39例)和对照组(39例)。治疗组滴用小牛血去蛋白提取物眼用凝胶联合吲哚美辛滴眼液，对照组滴用贝复舒滴眼液。小牛血、吲哚美辛和贝复舒皆滴眼每日4次，疗程为14 d，第1周每日观察、第2周隔日观察，观察项目包括患眼局部症状、体征和上皮缺损修复情况。结果治疗组视力提高27例(69%)，明显高于对照组(13例,占33%)，2组比较差异有统计学意义(χ2=10.06,P<0.01)；治疗组治疗PCED总有效率(92.3%)高于对照组(69.2%)，且差异有统计学意义(χ2=6.69，P<0.01)；治疗组治疗过程中未见局部刺激和全身不良反应。结论小牛血去蛋白提取物眼用凝胶联合吲哚美辛滴眼液治疗PCED疗效确切，优于贝复舒眼液，安全性高。

【关键词】吲哚美辛滴眼液；小牛血去蛋白提取物眼用凝胶；持续性角膜上皮缺损

DOI:10.3969/g.issn.0253-9802.2015.07.016

基金项目：漯河医学高等专科学校自然科学基金(2014-S-LMC21)

Abstract【】ObjectiveTo evaluate the clinical efficacy of protein-free calf blood extract eye gels combined with indometacin eye drops in treating persistent corneal epithelial defect (PCED). MethodsSeventy eight cases with PCED (15 eyes resulting from trauma, 16 from surgery, 23 from chemical burns, 18 from keratitis and 6 from unknown causes) were randomly divided into the treatment (n=39) and control groups (n=39). In the treatment group, patients were treated with protein-free calf blood extract eye gels combined with indometacin eye drops, and those in the control group were administered with by bFGF (basic fibroblast growth factor) eye drops alone. All medication was administered 4 times daily for consecutive 14 d. The parameters including local symptoms of the affected eyes, physical signs and epithelial defect repair were observed everyday during the 1`(st) week and every other day within the 2`(nd) week. ResultsIn the treatment group, 27 cases (69%) had improved visual acuity, significantly higher compared with 13 (33%) in the control group (χ2=10.06, P<0.01). The overall effective rate of protein-free calf blood extract eye gels combined with indometacin eye drops (92.3%) was significantly higher compared with that of bFGF eye drops (69.2%) (χ2=6.69, P<0.01). No topical stimulation or systemic adverse reactions were noted in the treatment group. ConclusionsProtein-free calf blood extract eye gels combined with indometacin eye drops is an efficacious and safe treatment of PCED, which is superior to bFGF eye drops.

收稿日期：(2015-01-06)

Clinical efficacy of protein-free calf blood extract eye gels combined with indometacin eye drops in the treatment of persistent corneal epithelial defectFengCaixia，ZhangJinghui.TheThirdAffiliatedHospitalofLuoheMedicalCollege,Luohe462002,China

【Key words】Indometacin eye drops; Protein-free calf blood extract eye gels; Persistent corneal epithelial defects

持续性角膜上皮缺损(PCED)，是一种较常见的眼表面疾病，是由于各种原因导致角膜上皮损害，延迟愈合，甚至不愈, 持续1周以上者，严重时可导致角膜溃疡、穿孔等严重并发症，临床治疗比较棘手。传统的治疗方法如绷带包扎、配戴软性接触镜、药物等，虽取得一定效果，但仍不够理想。我们从2011年4月至2014年4月在原有研究基础上采用小牛血去蛋白提取物眼用凝胶联合吲哚美辛滴眼液治疗39例PCED患者，并与贝复舒滴眼液[主要成分为重组牛碱性成纤维细胞生长因子(bFGF)]治疗39例PCED患者进行比较，取得满意疗效，现将结果报道如下[1]。……