血清FS、CA125联合检测在卵巢型子宫内膜异位症与卵巢良性肿瘤鉴别诊断中的应用*

血清FS、CA125联合检测在卵巢型子宫内膜异位症与卵巢良性肿瘤鉴别诊断中的应用*

彭英**

（萍乡市妇幼保健院妇产科 江西萍乡 337000）

摘 要目的：探讨血清卵泡抑素（follistatin，FS）、糖链抗原125（carbohydrate antigen125，CA125）联合检测在卵巢型子宫内膜异位症与卵巢良性肿瘤鉴别诊断中的应用价值。方法：选取2012年3月至2014年6月期间我院确诊治疗的卵巢型子宫内膜异位症患者38例作为异位组，同期选取卵巢良性肿瘤36例作为良性组，统计分析并采用电化学发光免疫法检测所有患者血清中FS、CA125表达水平。结果：异位组患者血清中FS、CA125表达水平明显高于良性组（P＜0.05）；在FS=1.53 mg/L时，对卵巢型子宫内膜异位症与卵巢良性肿瘤的鉴别诊断敏感度为61.36%，特异度为86.54%，准确度为84.51%，在CA125=25.42 U/ml时，鉴别诊断敏感度为83.32%，特异度为85.18%，准确度为90.25%，二者联合的鉴别诊断敏感度为93.26%，特异度为94.41%，准确度为97.14%。在鉴别诊断敏感度、特异度和准确度方面，FS联合CA125检测＞CA125检测＞FS检测（P<0.05）。结论：FS、CA125可作为鉴别诊断卵巢型子宫内膜异位症与卵巢良性肿瘤的重要参考指标，二者联合诊断具有更高的敏感度、特异度和准确度，值得临床作进一步推广。

关键词卵泡抑素 糖链抗原125 子宫内膜异位症 良性肿瘤

Application of the joint detection of serum follistatin and carbohydrate antigen125 in the differential diagnosis of ovarian endometriosis and benign tumor*

PENG Ying**(Department of Gynecology and Obstetrics, Maternal and Child Health-Care Hospital of Pingxiang City, Jiangxi 337000, China)

ABSTRACTObjective: To discuss the application value of the joint detection of serum follistatin (FS) and carbohydrate antigen125 (CA125) in the differential diagnosis of ovarian endometriosis and ovarian benign tumor. Methods: Thirty-eight patients with ovarian endometriosis and 36 patients with ovarian benign tumor in our hospital were selected and divided into an ectopic group and a benign group and the expression levels of FS and CA125 in serum determined by an electrochemical luminescence immunoassay were statistically analyzed. Results: The expression levels of FS and CA125 was higher in the ectopic group than in the benign group (P<0.05). The sensitivity, the specificity and the accuracy to the differential diagnosis of the ovarian endometriosis and the ovarian benign tumor were 61.36%, 86.54% and 84.51% when FS level was at 1.53 mg/L, and 83.32%, 85.18% and 90.25%, when CA125 level was at 25.42 U/ml and 93.26%, 94.41% and 97.14% when the joint detection was used in the differential diagnosis, respectively. The sequence of three detection methods in the sensitivity, specificity and accuracy was the joint detection of FS and CA125 >CA125 detection >FS detection (P<0.05). Conclusion: FS and CA125 levels can be used as important reference indexes for the differential diagnosis of ovarian endometriosis and benign tumor, while the joint detection shows higher sensitivity, specificity and accuracy and is worthy of further clinical promotion.

KEY WORDSfollistatin; carbohydrate antigen125; ovarian endometriosis; ovarian benign tumor

卵巢型子宫内膜异位症亦称卵巢巧克力囊肿，属于子宫内膜异位症的一种特殊病变，是指子宫内膜碎片脱

落和发生在卵巢上的瘤样病变，导致卵巢增大，形成内含陈旧性积血的囊肿，严重影响患者的生存质量[1-2]。而卵巢良性肿瘤是指发生在卵巢上的良性肿瘤病变，其组织学类型较为复杂，可表现为卵巢肿大，其B超、CT等检测表现与卵巢型子宫内膜异位症极为相似，临床上易发生误诊错诊，降低对患者的治疗效果[3]。因此，寻找更有效鉴别诊断卵巢型子宫内膜异位症与卵巢良性肿瘤的标志物具有重要的临床意义。为……