阿托伐他汀强化治疗脑梗死并颈动脉易损斑块临床疗效观察

张逊娟 王 贺

阿托伐他汀强化治疗脑梗死并颈动脉易损斑块临床疗效观察

张逊娟 王 贺

目的 观察阿托伐他汀强化治疗脑梗死并颈动脉易损斑块的临床效果。方法 选择2013年3月～2015年8月我院收治的脑梗死并颈动脉易损斑块患者96例，随机分为研究组和对照组，每组48例，在常规内科治疗的基础上，对照组加用每日10 mg阿托伐他汀治疗，研究组加用每日40 mg阿托伐他汀治疗。治疗6个月后，比较两组治疗前后LDL-C和颈动脉易损斑块面积、内中膜厚度的变化。结果 治疗后，研究组LDL-C、颈动脉易损斑块面积以及IMT均优于治疗前，研究组治疗后上述指标优于对照组治疗后（P＜0.05）。结论 阿托伐他汀强化治疗脑梗死并颈动脉易损斑块可以改善患者的血脂水平，稳定颈动脉易损斑块。

阿托伐他汀；强化治疗；脑梗死；颈动脉易损斑块

doi：10.3969/j.issn.1674-9316.2016.13.074

【Abstract】

Objective To observe the clinical effect of atorvastatin in the treatment of cerebral infarction with vulnerable plaque of carotid artery. Methods From 2013 March to August 2015， 96 cases with cerebral infarction and carotid plaque in patients in our hospital were randomly divided into study group and control group，48 cases in each group. On the basis of routine therapy，the control group was treated with 10 mg atorvastatin treatment，the study group and with every day 40 mg atorvastatin . After 6 months of treatment，the changes of LDL-C and carotid artery intima-media thickness and plaque area before and after treatment between the two groups were analyzed. Results After treatment，the study group LDL-C，vulnerable plaque area of carotid artery and IMT were significantly better than before treatment，the study group after treatment was also significantly better than the control group after treatment（P＜0.05）. Conclusion Atorvastatin intensive treatment of cerebral infarction and carotid vulnerable plaque can significantly improve the blood lipid levels of patients with stable carotid vulnerable plaque.

【Key words】Atorvastatin，Intensive treatment，Cerebral infarction，Carotid vulnerable plaque

脑梗死是常见的神经系统疾病，动脉粥样硬化（AS）是发病的重要原因之一［1］。因此，积极干预动脉粥样硬化形成是预防缺血性脑卒中发生的重要措施［2］。临床研究已经证实，他汀类药物具有良好的调节血脂代谢的作用。本研究采用阿托伐他汀强化治疗的方法治疗脑梗死并颈动脉易损斑块，效果理想，现报告如下。

1　资料与方法

1.1一般资料

选择2013年3月～2015年8月我院收治的脑梗死并颈动脉易损斑块患者96例，随机分为研究组和对照组，每组48例。所有患者均经头颅CT或MRI确诊为前循环脑梗死，均符合缺血性卒中的诊断标准［3］。其中研究组男29例，女19例；年龄41～78岁，平均年龄（61.5±11.6）岁。……