硫酸镁联合硝苯地平对妊娠高血压患者血小板活性物质和抗氧化能力的影响

崔伏琴

[摘要] 目的 观察硫酸镁联合硝苯地平治疗妊娠高血压疾病时对血小板活性物质和抗氧化能力指标的影响。 方法 随机将136例妊娠高血压患者均分为两组，对照组予单纯用硫酸镁治疗，观察组予硫酸镁联合硝苯地平治疗，分别检测治疗前及治疗后5 d末的血小板活性物质和抗氧化能力指标。 结果 两组均能够改善治疗后血小板活性物质指标和抗氧化能力指标，但观察组血小板活性物质指标、抗氧化能力指标改善幅度优于对照组（P<0.05）。结论 硫酸镁联合硝苯地平在治疗妊高征患者的过程中，对血小板活性物质和抗氧化能力的改善优于单纯使用硫酸镁治疗，可有效发现患者的各种疾病状态。

[关键词] 妊娠高血压；硫酸镁；硝苯地平；血小板活性物质；抗氧化能力指标

[中图分类号] R714.246[文献标识码] B[文章编号] 1673-9701（2014）19-0048-03

Influence of magnesium sulfate combined with nifedipine on blood platelet active substances and antioxidant capacity of patients with gestational hypertension

CUI Fuqin

Department of Obstetrics and Gynecology, Anyang Hospital of Traditional Chinese Medicine in Henan Province, Anyang 455000, China

[Abstract] Objective To observe the influence of magnesium sulfate combined with nifedipine treatment on the blood platelet active substances and antioxidant capacity of patients with gestational hypertension. Methods A total of 136 patients with gestational hypertension were equally randomly divided into two groups. The control group received single magnesium sulfate treatment while the observation group received magnesium sulfate combined with nifedipine treatment. The blood platelet active substances and antioxidant capacity indicators before treatment and at the end of day 5 after treatment were detected respectively. Results The blood platelet active substances indicators and antioxidant capacity indicators of both groups were better after treatment, but the decrease degree of the observation group was better than that of the control group(P<0.05). Conclusion In the treatment process of patients with gestational hypertension, magnesium sulfate combined with nifedipine is better than single magnesium sulfate in the improvement of blood platelet active substances and antioxidant capacity and can effectively discover the patients various disease status.

[Key words] Gestational hypertension; Magnesium; Nifedipine; Blood platelet active substances; Antioxidant capacity indicator

妊娠高血压（简称妊高征），是妊娠期妇女所特有而又常见的疾病，可呈现出血小板的高度活化状态，同时也可出现抗氧化能力减低，这些症状会对孕妇和胎儿造成不利的影响，甚至发生母婴死亡。对轻、中度妊高征患者适当应用降压药物，可减少重度妊高征及胎儿窘迫的发生率，有利于降低剖宫产率及母婴死亡率[1]。本研究发现监测硫酸镁联合硝苯地平对血小板活性物质和抗氧化能力等实验室指标能有效地预测疾病的发展和转归[2]。具体结果报道如下。

1 资料与方法

1.1 临床资料

研究对象为安阳市中医院妇产科2010年1月～2013年12月136例妊高症患者，经实验室检查和临床体征确诊，采用随机数字表法分为对照组和观察组各68例。对照组年龄20～38岁，平均（29.5±3.9）岁；孕周33.7～40.4周，平均（37.8±3.4）周；初产妇53例，经产妇15例；妊高征中度30例，重度38例。……