上海市青浦区朱家角人民医院参附注射液应用分析

项奇珍，吴莉萍，盛春琴(上海市青浦区朱家角人民医院药剂科，上海　201713)



上海市青浦区朱家角人民医院参附注射液应用分析

项奇珍*，吴莉萍，盛春琴(上海市青浦区朱家角人民医院药剂科，上海201713)

DOI10.14009/j.issn.1672-2124.2016.02.030

摘要目的：调查分析上海市青浦区朱家角人民医院(以下简称“我院”)参附注射液临床应用情况，以促进临床合理用药。方法：抽取我院2013年1—12月住院患者使用参附注射液的病历医嘱单286份，结合药品说明书和《中药注射剂临床使用基本原则》对患者的基本信息，用量、用法，临床诊断，溶剂，给药途径，滴数，疗程以及不良反应，用药费用等进行统计和分析。结果：参附注射液在我院临床广泛应用，科室涉及外科、骨科、内科等，涉及病症包括阑尾炎手术、胆囊疾病手术、急性胰腺炎、斜疝手术、外伤骨折手术、肛门疾病以及心血管疾病等；应用参附注射液1～3 d病例数最多，分别为48、61、45例；与其他药物混合配伍13.81%，两种中药注射液联用7.46%；1例患者用法不规范、滴数控制仅3例注明缓慢滴注、2例有药物过敏史使用中药注射液。结论：我院参附注射液在选择目标病症、扩大病种、使用方法、疗程以及不良反应的观察等方面存在一定的问题与不足。运用循证医学加强上市后的药物评价、临床科学合理的使用，中药注射剂必将更好地为健康服务。

关键词参附注射液； 调查分析； 合理用药

Analysis on Application of Shenfu Injection in Shanghai Qingpu District Zhujiajiao People’s Hospital

XIANG Qizhen, WU Liping, SHENG Chunqin(Dept.of Pharmacy, Shanghai Qingpu District Zhujiajiao People’s Hospital, Shanghai 201713, China)

ABSTRACTOBJECTIVE：To investigate and analyze the clinical application of shenfu injection in Shanghai Qingpu District Zhujiajiao People’s Hospital(hereinafter referred to as “our hospital”), so as to promote the rational drug use in clinic. METHODS: 286 inpatient medical orders with application of shenfu injection from Jan. to Dec. 2013 were extracted, combined with drug instruction and Basic Principles of Traditional Chinese Medicine Injection in Clinical Use, patients’ general information, usage and dosage, clinical diagnosis, solvent, route of administration, drips, treatment course, adverse reactions and medication expenses, etc, were statistically analyzed. RESULTS: Shenfu injection was widely used in many departments of our hospital, including department of surgery, orthopaedics and internal medicine, etc; and in many diseases including appendectomy, gallbladder disease surgery, acute pancreatitis, oblique hernia surgery, traumatic fracture surgery, anorectal disease and cardiovascular disease, etc. The number of patients with shenfu injection for 1～3 d took the lead, were respectively 48, 61 and 45 cases. The compatibility of medicines was 13.81%, combination of two kinds of traditional Chinese medicine injection was 7.46%. There were 1 patient with improper usage, 3 patients with clear indication of slow drip and 2 patients of drug allergy history with traditional Chinese medicine injection. CONCLUSIONS: There are some problems and deficiencies in the selection of target diseases, expansion of disease, application methods, treatment course and observation on adverse reactions of shenfu injection. With the rational application of drug evaluation, clinical science strengthened by evidence-based medicine, the traditional Chinese medicine injection can better serve the public health.

KEYWORDSShenfu injection; Investigation and analysis; Rational drug use

参附注射液主要化学成分为人参皂苷、乌头生物碱，临床上广泛应用于心力衰竭、各种原因的休克、心肌梗死等疾病的治疗。……