规则抗菌疗法治疗复发性尿路感染

冯丽娟

[摘 要] 目的：探讨规则抗菌疗法治疗复发性尿路感染（Urinary tract infection，UTI）疗效。 方法：选取我院2010年3月—2014年3月收治的104例复发性UTI患者，随机分为规则抗菌组及常规抗菌组，各52例。2组患者分别接受规则抗菌疗法、胸腺五肽联合常规抗菌疗法治疗，比较其症状缓解时间、疗效及复发情况。结果：2组患者症状缓解、症状消失时间差异无统计学意义，规则抗菌组治疗时间显著低于常规抗菌组，差异有统计学意义。2组患者治疗前、疗程结束后血清Cr、BUN、UA水平均未见明显变化，差异无统计学意义（P>0.05）。规则抗菌组总有效率为90.4%，显著高于常规抗菌组的59.6%，其复发率为9.6%（5/52），亦显著低于常规抗菌组的53.8%（28/52），差异有统计学意义（P<0.05）。结论：规则抗菌疗法能够显著缩短患者症状改善及治疗时间，在不增加肾毒性的前提下有效保证临床疗效，降低UTI复发率。

[关键词] 规则抗菌疗法；分期治疗；复发性尿路感染

中图分类号：R691.3 文献标识码：A 文章编号：2095-5200（2016）02-113-03

DOI：10.11876/mimt201602044

[Abstract] Objective： To investigate the rule antimicrobial therapy for recurrent UTI （urinary tract infection） effect. Methods： 104 patients admitted in our hospital with recurrent UTI from March 2010 to March 2014 were randomly divided into rule antimicrobial group and conventional antibacterial group， 52 cases each. Patients of 2 groups were receiving rule antimicrobial therapy； thymopentin united conventional antimicrobial therapy， and compared time for relieving symptoms， efficacy and recurrence. Results： The difference in symptoms relieving， the time for symptoms disappearing of two groups was not statistically significant. The therapy time of rule antimicrobial treatment group was significantly lower than that of conventional antimicrobial group， and the difference was statistically significant. Levels of serum Cr， BUN and UA of two groups patients before and after treatment showed no significant change， and the difference was not statistically significant （P>0.05）. Total effective rate of rule antimicrobial was 90.4%， it was significantly higher than 59.6% of conventional antimicrobial group， the recurrence rate was 9.6% （5/52）， it was also significantly lower than 53.8% （28/52） of conventional antimicrobial group， and the difference was statistically significant （P<0.05）. Conclusions： Rule antimicrobial therapy can significantly reduce the time for relieving symptoms and treating， and effectively ensure clinical efficacy and reduce the recurrence rate of UTI under the premise of not increasing nephrotoxicity.

[Key words] rule antimicrobial therapy；stage treatment；recurrent urinary tract infections

約有30%女性一生中曾发生尿路感染（Urinary tract infection，UTI）[1]。该病临床症状特异性低、病程长、难以治愈，且易复发，常引发肾间质病变，严重者可出现肾功能衰竭[2]。但随着抗菌药物、免疫抑制剂、激素等药物广泛应用，导致UTI患者疾病迁延难愈、病情反复。规则抗菌疗法又称抗菌药物分期疗法，是按照患者治疗分期调整抗菌药物剂量的一种治疗方案，近年来在感染性疾病治疗中受到了广泛关注[3]。为观察规则抗菌疗法治疗复发性UTI临床效果，本文选取我院2010年3月—2014年3月收治104例复发性UTI患者进行病例对照研究，研究过程与结论如下。

1 一般资料

1.1 病例资料

选取我院2010年3月—2014年3月收治104例65岁以下复发性UTI患者，按照随机数字表法分为规则抗菌组及常规抗菌组，各52例。复发……