印片细胞学与快速冰冻联合在甲状腺肿瘤术中病理诊断价值

任玉宝

[摘要] 目的 分析印片细胞学与快速冰冻在甲状腺肿瘤术中病理诊断方面的价值。方法 病例来源为整群选取该院外科行手术治疗的甲状腺肿瘤患者，共50例。对患者临床资料展开回顾分析，并以石蜡切片诊断结果为评估标准，对单纯印片细胞学、单纯快速冰冻切片、以及印片细胞学联合快速冰冻切片对甲状腺肿瘤的术中病理诊断结果进行对比分析。 结果 单纯印片细胞学对甲状腺肿瘤的术中病理诊断准确率为86.00%（43/50）；单纯冰冻切片对甲状腺肿瘤的术中病理诊断准确率为84.00%（42/50）；印片细胞学联合快速冰冻对甲状腺肿瘤的术中病理诊断准确率为98.00%（49/50）。组间数据对比，印片细胞学联合快速冰冻对对甲状腺肿瘤的术中病理诊断准确率明显高于其他两种方法，差异有统计学意义（P<0.05）。 结论 将印片细胞学与快速冰冻切片法联合应用于对甲状腺肿瘤的术中病理诊断，可相互弥补，减少误诊率，提高术中病理快速诊断的准确性。

[关键词] 甲状腺肿瘤；印片细胞学；快速冰冻；病理诊断

[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2016）03（c）-0053-03

Pathological Diagnosis Value of Printed Cytology Combined with Fast Frozen in Thyroid Tumor Operation

REN Yu-bao

Department of Pathology， Laiwu Central Hospital of Xinwen Mining Group， Laiwu， Shandong Province， 271103 China

[Abstract] Objective To analyze the pathological diagnosis value of printed cytology combined with fast frozen in thyroid tumor operation. Methods 50 cases of patients with thyroid tumor operation？in the surgical department of our hospital from February 2015 to September 2015 were selected， the clinical data of the patients were retrospectively analyzed， the pathological diagnosis results of the simple printed cytology， simple fast frozen sections and printed cytology combined with fast frozen sections in thyroid tumor operation were compared and analyzed. Results The pathological diagnosis accuracy rates of the simple printed cytology， fast frozen and printed cytology combined with fast frozen in thyroid tumor operation were respectively 86.00% （43/50）， 84.00% （42/50） and 98.00% （49/50）， the data showed that the pathological diagnosis accuracy rate of printed cytology combined with fast frozen sections was obviously higher than that of the other two methods， and the difference was obvious with statistical significance（P<0.05）. Conclusion Printed cytology combined with fast frozen sections in the application of pathological diagnosis in thyroid tumor operation can make up for each other， decrease the misdiagnosed rate and improve the accuracy of pathological rapid diagnosis in operation.

[Key words] Thyroid tumor； Printed cytology； Fast frozen； Pathological diagnosis

已有研究资料中认为虽然目前穿刺细胞学以及影像学技术在有关甲状腺肿瘤疾病的诊断中仍然发挥中确切的作用，但受到病变不均质性以及诊断材料收集不确定性等因素的影响，直视常规的穿刺诊断准确性不甚理想[1]。而近年来随着环保型立式恒冷箱式冰冻切片机在临床中的推广应用，快速冰冻技术为术中病理诊断带来了一定的方便，且在制片厚度上存在非常确切的优势[2-3]。同时有关研究中认为[4]，在对患者行冰冻切片的同时联合印片细胞学技术，两者相互结合与补充，对提高诊断准确率，降低冰冻切片误诊率有积极效果，值得推广。……