中药复方口服对稳定型心绞痛患者血脂及脂肪因子的影响*

张　　淼　　陈　　民（1.辽宁中医药大学，辽宁 沈阳 110033；.辽宁中医药大学附属医院，辽宁 沈阳 110033）



中药复方口服对稳定型心绞痛患者血脂及脂肪因子的影响*

张淼1，2陈民2
（1.辽宁中医药大学，辽宁 沈阳 110033；2.辽宁中医药大学附属医院，辽宁 沈阳 110033）

目的 观察中药复方口服联合基础西药治疗对稳定型心绞痛（痰瘀互结证）的临床疗效。方法 将100例患者根据就诊顺序利用DPS软件随机分为两组，各50例，两组均给予常规的西药基础治疗，治疗组在对照组治疗基础上，加用本院自制中药复方口服1个月。结果 治疗组的总有效率为88.00%，明显高于对照组的72.00%（P＜0.01）。治疗后两组血脂水平均较治疗前明显改善（P＜0.01）；与对照组比较，治疗组改善更加明显（P＜0.01）。两组治疗后脂肪因子均较治疗前明显改善（P＜0.01）；与对照组比较，治疗组改善更加明显（P＜0.01）。结论 中药复方可能通过调脂、升高脂联素，降低抵抗素水平发挥治疗心绞痛的作用。

稳定型心绞痛血脂脂联素抵抗素

【Abstract】Objective：To explore the clinical effects of Chinese herbal compound combined with basic Western medical therapy on syndrome of intermin-gled phlegm and blood stasis of stable angina pectoris.Methods：100 stable angina patients with syndrome of intermin-gled phlegm and blood stasis were randomly divided into the observation group and the control group，50 cases in each.The two group used basic Western medical therapy，and the observation group took additional Chinese herbal compound for 1 month.Results：The total effective rate of angina of the observation group was 88%，which was significantly higher than that of the control group 72.00% （P<0.01）.After treatment，the blood lipid levels of the two groups were significantly improved compared with those before treatment（P<0.01）.Compared with the control group，the improvement of the observation group was more obvious（P<0.01）.After treatment，adipocytokines of the two groups were significantly improved than before treatment（P<0.01）.Compared with the control group，the improvement of the observation group was more obvious （P<0.01）.Conclusion：Chinese herbal compound may be effective on treating stable angina patients by regulating lipid，raising adiponectin and decreasing resistin.

【Key words】Stable angina；Blood lipids；Adiponectin；Resistin

冠心病心绞痛是指由于冠状动脉的供血绝对或相对不足，心肌细胞缺血、缺氧所引发的以阵发性胸痛、胸部不适等症状为主要临床表现的综合征，病因为动脉管壁的粥样硬化［1］。该类人群中肥胖及超重患者比例很高，肥胖及脂代谢紊乱是导致冠心病发生的重要因素［2］。脂肪组织是人体内最大的内分泌器官，脂肪细胞能分泌多种生物活性物质，即脂肪细胞因子，如脂联素（APN）、抵抗素等，调节人体的胰岛素敏感性、能量消耗、炎症反应等等，均与冠心病疾病的发生、发展过程密切相关。……