长航对女性黄褐斑的影响研究

刘启方，孙 涛，杨闰平，李晓鹏

长航对女性黄褐斑的影响研究

刘启方，孙 涛，杨闰平，李晓鹏

目的 分析长航对女性黄褐斑的影响。方法 选取参加长航任务的17例女性黄褐斑患者（黄褐斑组），并设对照组15例健康女性（健康组），检测长航前、后症状及血清促黑素细胞激素、过氧化脂质、超氧化物歧化酶水平的变化。结果 长航3个月后黄褐斑患者皮损面积和颜色较长航前均不同程度扩大和加深（P＜0.05），伴随症状失眠、便秘、月经不调均不同程度加重（P＜0.05）。黄褐斑组和健康组长航3个月后血清促黑素细胞激素水平均较前升高（P＜0.05），黄褐斑组血清促黑素细胞激素长航前、后较健康组均高（P＜0.05）；黄褐斑组长航3个月后过氧化脂质水平升高、超氧化物歧化酶水平降低（P＜0.05），而健康组长航前、后差异无统计学意义（P＞0.05）。结论 长航能使黄褐斑皮损扩大、颜色加深，伴随症状加重，并使黄褐斑患者的血清促黑素细胞激素和过氧化脂质水平升高、超氧化物歧化酶水平降低。

黄褐斑；促黑素细胞激素；过氧化脂质；超氧化物歧化酶；长航

［Abstract］Objective To analyze the influence of long-term sailing for the female melasma patients.Methods Before long-term sailing and after 3 months，17 female melasma patients were selected to analyze their symptoms and detect the levels of melanocyte-stimulating hormone（MSH），lipoperoxide（LPO），superoxide dismutase（SOD）.15 normal women were enrolled in the control group，all of participator would involved in one of the long-term sailings.Results Compared with before，the scores of skin lesion area and color were increased in 3 months（P＜0.05），and the accompanying symptoms including insomnia，constipation and menoxenia became more serious（P＜0.05）. After 3 months，the MSH level of melasma patients and nomal women both increased significantly （P＜0.05），but the change value of MSH in melasma group was greater than that in control group （P＜0.05），the level of LPO increased and SOD decreased（P＜0.05）in melasma group，however in control group the levels of LPO and SOD showed no significant differences between before and after long-term sailing（P＞0.05）.Conclusion Long-term sailing can markedly enlarge the size and thicken the color of melasma，aggratate the accompanying symptoms of patients，increase LPO and MSH levels and decrease the SOD level.

［Key words］Melasma；Melanocyte-stimulating hormone（MSH）；Lipoperoxide（LPO）；Superoxide dismutase（SOD）；Long-term sailing

黄褐斑是一种常见色素沉着性皮肤病，好发于中年女性面部，且难以治愈。多数学者认为黄褐斑主要与内分泌失调、遗传、日晒等因素相关［1-2］。海军长航任务对人内分泌、神经系统、睡眠、饮食方面均存在一定的影响，进而可能影响黄褐斑发生、发展。本研究利用3次“和谐使命”长航任务调查17例女性黄褐斑患者症状并检测其激素、活性酶的水平变化，分析长航对女性黄褐斑的影响。……