探讨不同种类抗生素治疗呼吸道感染的药学效果

张永慧内蒙古赤峰市学院附属医院药房，内蒙古赤峰　024000

探讨不同种类抗生素治疗呼吸道感染的药学效果

张永慧
内蒙古赤峰市学院附属医院药房，内蒙古赤峰024000

目的研究并探讨不同种类抗生素治疗呼吸道感染的药学效果。方法在该院2013年1月—2015年12月期间应用抗生素的呼吸道感染病例资料中，随机选取应用头孢曲松、头孢唑肟、左氧氟沙星、阿奇霉素治疗的呼吸道感染病例资料各50份进行回顾性研究分析，分别设置为头孢曲松组、头孢唑肟组、左氧氟沙星组以及阿奇霉素组，对其用药情况进行分析和总结，观察和对比4种抗生素药物应用后的治疗总有效率、药物不良反应发生率以及成本-效果。结果4组抗生素的治疗总有效率分别为94%、92%、94%、96%，四组相比，差异无统计学意义（P＞0.05）。4组病例资料中的患者均未出现明显的不良反应。四组的成本-效果从高至低依次排列为头孢曲松组、头孢唑肟组、阿奇霉素组、左氧氟沙星组。结论在呼吸道感染的临床治疗中，头孢曲松、头孢唑肟、左氧氟沙星以及阿奇霉素均具有显著的治疗效果和安全性，临床用药时可根据患者的具体情况进行选择。

呼吸道感染；抗生素；药学

［Abstract］Objective To study and discuss the pharmaceutical effects of different antibiotics in the treatment of respiratory tract infections.Methods The clinical data of 50 were retrospectively analyzed in 12 years during January 2013 to December 2015 antibiotics in our hospital respiratory infection data were randomly selected，with ceftriaxone，ceftizoxime，levofloxacin，azithromycin in the treatment of respiratory infection，were set for ceftriaxone group，ceftizoxime group，group of levofloxacin and azithromycin group and the drug were analyzed and summarized，observation and comparison of four kinds of antibiotics application after treatment，the total efficiency，adverse drug reactions occur rate and cost-effectiveness.Results Total effective rate 94%，92%，94%and 96%，respectively in the four groups of antibiotics treatment，four groups are compared，the difference was not statistically significant（P＞0.05）.There were no significant adverse reactions in the four groups of patients.Four groups of cost-effectiveness from high to low are sequentially arranged for ceftriaxone group，ceftizoxime group，azithromycin and levofloxacin group.Conclusion In the clinical treatment of infection in respiratory，ceftriaxone，ceftizoxime，levofloxacin and azithromycin has significant therapeutic effect and safety and clinical medication can choose according to the specific circumstances of the patients.

［Key words］Respiratory tract infection；Antibiotics；Pharmacy

呼吸道感染是一类常见的临床疾病，主要是由病原菌入侵而导致的呼吸道炎症反应，临床表现以咳嗽、咳痰、呼吸急促等症状为主，对患者的生活造成严重的影响［1］。临床上多采用抗生素进行治疗，常用的抗生素有头孢曲松、头孢唑肟、左氧氟沙星、阿奇霉素等，但采用何种抗生素更加有效和安全尚无定论［2］。……