替诺福韦酯联合拉米夫定治疗艾滋病合并乙型肝炎病毒感染分析

高化国吉林公安边防总队通化支队，吉林通化　134001

替诺福韦酯联合拉米夫定治疗艾滋病合并乙型肝炎病毒感染分析

高化国
吉林公安边防总队通化支队，吉林通化134001

目的分析替诺福韦酯联合拉米夫定治疗艾滋病合并乙型肝炎病毒感染的临床疗效。方法选择2012年3月—2015年3月该院收治的艾滋病合并乙型肝炎病毒感染患者70例，将所有患者随机分为观察组与对照组，各35例。对照组单纯采用拉米夫定治疗，观察组在此基础上联合应用替诺福韦酯治疗。对比两组患者治疗后HBV（乙肝病毒）DNA低于检测下线率、血清HBV DNA含量及HIV RNA转阴率。结果观察组治疗6个月、12个月后HBV DNA低于检测下限率分别为48.57%、71.43%，对照组分别为25.71%、42.86%，观察组明显高于对照组，差异显著（P＜0.05）；观察组治疗6、12个月后血清HBV DNA含量分别为（3.21±1.19）mL、（2.03±0.09）mL，对照组分别为（4.70±1.24）mL、（3.35±1.05）mL，观察组明显低于对照组，差异有统计学意义（P＜0.05）；观察组HIV RNA转阴率明显高于对照组，差异有统计学意义（P＜0.05）。结论联合替诺福韦酯与拉米夫定治疗艾滋病合并乙型肝炎病毒感染临床疗效确切，可有效抑制病毒扩散，保护肝脏，值得推广。

替诺福韦酯；拉米夫定；艾滋病合并乙型肝炎

［Abstract］Objective To analyze the clinical efficacy of tenofovir and lamivudine in treatment of AIDS complicated with hepatitis B virus infection.Methods From March 2012 to March 2015 in our hospital of AIDS complicated with hepatitis B virus infection in 70 patients，all patients were randomly divided into observation group and control group，35 cases in each group.The control group was treated with lamivudine treatment，observation group based on the combined application of tenofovir therapy.The two groups were compared after treatment of HBV（hepatitis B virus）DNA below the detection line rate，serum HBV content of DNA and HIV RNA negative rate.Results Observation group treatment for 6 months，12 months after HBV DNA below the detection limit rates were 48.57%，71.43%，the control group were 25.71%，42.86%，significantly higher than the observation group，the difference was significant（P＜0.05）；observation group treatment for 6 months，12 months after the serum HBV DNA levels were（3.21±1.19）mL，（2.03± 0.09）mL，control group were（4.70±1.24）mL，（3.35±1.05）mL observation group was significantly lower than the control group，the difference was significant（P＜0.05）；the observation group was significantly higher HIV RNA negative rate，the difference was significant（P＜0.05）.Conclusion The combination of tenofovir and lamivudine in the treatment of AIDS patients with hepatitis B virus infection in clinical curative effect of it Cut，can effectively inhibit the spread of the virus，protect the liver，it is worth promoting.

［Key words］Knoff Vee；Lamivudine；Hepatitis B

艾滋病是指人体免疫系统受HIV病毒 （人类免疫缺陷病毒）侵害的，极具危害性的一种传染病，由于该病患者免疫系统被严重破坏，免疫功能丧失，导致其感染其他疾病的可能性非常大，同时也增加了病死率［1］。乙型肝炎是一种因乙肝病毒（HBV）引起的肝脏炎性病变，并伴有多种器官损伤的疾病，是危害我国公共卫生安全的重要因素［3］。……