耳后注射甲泼尼龙琥珀酸钠治疗突发性耳聋的临床疗效

陶静　王小飞　丁莉

[摘要] 目的 分析耳后注射甲潑尼龙琥珀酸钠治疗突发性耳聋的临床疗效。 方法 选择2015年1月～2016年5月至我院就诊的84例突发性耳聋患者，采取信封随机分组方案分为常规组与实验组，分别采取银杏叶提取物注射液与耳后注射甲泼尼龙琥珀酸钠进行治疗，对比两组患者的治疗效果。 结果 实验组总有效率为97.62%，显著高于常规组（85.71%）（P<0.05）；治疗前，两组患者的纯音听阈值无显著差异（P>0.05），治疗后实验组患者的纯音听阈值明显优于常规组（P<0.05）；治疗前两组患者的白细胞计数、红细胞计数、血小板计数、淋巴细胞计数无明显差异（P>0.05），治疗后实验组血小板计数明显低于常规组（P<0.05）。 结论 对突发性耳聋患者采取耳后注射甲泼尼龙琥珀酸钠进行治疗的疗效显著，可帮助患者有效改善听力，值得实践推广。

[关键词] 突发性耳聋；甲泼尼龙琥珀酸钠； 白细胞；淋巴细胞；血小板

[中图分类号] R764.437 [文献标识码] B [文章编号] 1673-9701（2017）04-0071-03

Clinical efficacy of posterior aural injection of methylprednisolone sodium succinate in the treatment of sudden deafness

TAO Jing1 WANG Xiaofei1 DING Li2

1.Department of ENT and Head and Neck， Lishui People's Hospital in Zhejiang Province， Lishui 323000， China； 2.Department of Endocrinology， Lishui People's Hospital in Zhejiang Province， Lishui 323000， China

[Abstract] Objective To evaluate the clinical efficacy of posterior aural injection of methylprednisolone sodium succinate in the treatment of sudden deafness. Methods A total of 84 patients with sudden deafness who were diagnosed in our hospital from January 2015 to May 2016 were selected. They were randomly divided into conventional group and experimental group according to the protocol of envelop randomization. Ginkgo biloba extract injection and posterior aural injection of methylprednisolone sodium succinate were adopted for treatment. The therapeutic effects were compared between the two groups. Results The total effective rate was 97.62% in the experimental group， which was significantly higher than that in the conventional group（85.71%） （P<0.05）； before the treatment， there was no significant difference in pure tone threshold between the two groups（P>0.05）. The pure tone threshold in the experimental group was significantly better than that in the control group after the treatment（P<0.05）； there were no significant differences in leukocyte count， red blood cell count， platelet count and lymphocyte count between the two groups before treatment （P>0.05）. After the treatment， the platelet count in the experimental group was significantly lower than that in the conventional group（P<0.05）. Conclusion Posterior aural injection of methylprednisolone sodium succinate is effective for the patients with sudden deafness， which can help patients improve their hearing effectively， and is worthy of practice and promotion.

[Key words] Sudden deafness； Methylprednisolone sodium succinate； Leukocytes； Lymphocytes； Platelets

突发性耳聋作为一种临床治疗过程中常见的病症，由不明原因引起的一类神经性听力损伤，其特点是起病急和病情发展迅速，主要临床症状包括听力下降、耳鸣、眩晕等，需及时采取科学有效的方法进行临床干预，帮助患者及时改善听力[1，2]。目前临床上主要采取药物注射治疗，但是临床数据表明口服和静脉注射的方式，均无法将药物经血-迷路屏障进入内淋巴结，临床上全身给药方式应用受限，鼓室内给药方式的不良反应概率增大。为此，本次研究采取耳后给药方式进行治疗，现报道如下。

1 资料与方法

1.1 一般资料

选择2015年1月～2016年5月至我院就诊的84例突发性耳聋患者，纳入标准：（1）所有患者均经过临床常规诊断后显示疾病被确诊；（2）均在知情同意的前提下纳入本次实验。排除标准：将合并内耳畸形、中耳炎、桥小脑角或者内听道占位性病变患者、糖尿病、高血压、精神疾病、活动性消化性溃疡、肿瘤患者排除。……