改性纱布防止兔盲肠、子宫术后盆腔粘连的效果观察

吴昌媛+焦爱军

【摘要】 目的：观察改性纱布防止兔盲肠、子宫术后盆腔粘连的效果。方法：将若干只雌性新西兰大白兔随机分为空白对照组和改性纱布组，在盲肠、左侧子宫使用刮匙人为制造创伤，空白对照组予2 ml生理盐水涂布创面，改性纱布组用改性纱布2 cm×2 cm包覆创面。术后14 d处死动物，肉眼观察两组动物创面粘连情况，评分，并进行病理形态学的观察。结果：改性纱布组与空白对照组比较，盆腔粘连等级显著低，差异有统计学意义（P<0.05），改性纱布组粘连等级总分值高。结论：改性纱布具有防止兔盲肠、子宫术后盆腔粘连的作用。

【关键词】 改性纱布； 兔； 子宫； 盲肠； 盆腔粘连

doi：10.14033/j.cnki.cfmr.2017.15.078 文献标识码 B 文章编号 1674-6805（2017）15-0140-03

Observation on the Effect of Modified Gauze on Preventing Post-operative Pelvic Adhesion of Rabbit Cecum and Uterus/WU Chang-yuan，JIAO Ai-jun.//Chinese and Foreign Medical Research，2017，15（15）：140-142

【Abstract】 Objective：To study the effect of modified gauze on preventing post-operative pelvic adhesion of rabbit cecum and uterus.Method：In the experiment，a number of New Zealand white rabbits were randomly divided into two groups for comparison purposes.Artificial wounds were made to the left side of uterus of all rabbits using a curette.Rabbits of one group were treated with 2 ml saline normally.In another group，the wounds were treated with a 2 cm×2 cm modified gauze applied.All rabbits were set to death humanly two weeks after the operation.The wound healing condition of rabbits in the two groups were observed，and pathological analysis of the two groups were conducted.Result：The level of pelvic adhesion in the modified gauze group was significantly lower than that of the blank control group，the difference was statistically significant（P<0.05）.The total scores of the level of pelvic adhesion in the modified gauze group were higher.Conclusion：The experiment proves that the modified gauze can effectively improve wound healing and prevent post-operative pelvic adhesion of rabbit cecum and uterus.

【Key words】 Modified gauze； Rabbit； Uterus； Cecum； Pelvic adhesion

First-authors address：Pharmaceutical College of Guangxi Medical University，Nanning 530021，China

盆腔粘連是妇科手术后常见的并发症[1]，粘连导致的临床严重并发症包括：肠梗阻、慢性盆腔痛、不孕及不育等，增加了再次手术的困难及进一步发生并发症的潜在性，预防粘连的目的是在保证正常伤口愈合和避免感染的前提下，消除或者减少粘连的发生率和严重程度[2-4]。本实验通过在新西兰大白兔体内构建盆腔粘连模型，受损部位放置改性纱布，术后14 d观察其防粘连的效果，为其临床应用于术后盆腔粘连的预防提供理论基础。

1 材料与方法

1.1 实验动物

新西兰大白兔28只，雌性，未孕，5～6个月龄，体重2.5～3.0 kg，清洁级，由广西医科大学实验动物中心提供，实验动物使用许可证号：SCXK桂2014-0002。术前适应性饲养1周，剔除不合格动物。随机分组，盲肠：空白对照组、改性纱布组，各6只；子宫：空白对照组、改性纱布组，各8只。标准兔颗粒饲料分笼饲养，自由饮水。

1.2 实验材料

改性纱布：惠州华阳医疗器械有限公司，规格6 cm×8 cm，批号20151124002。……