5—氟尿嘧啶与吉西他滨联合同期放疗治疗局部进展胰腺癌的临床效果

叶世富+陈炀+首峰+林远洪+叶岭

[摘要] 目的 探討5-氟尿嘧啶与吉西他滨联合同期放疗治疗局部进展胰腺癌的临床效果。 方法 回顾性分析四川省简阳市人民医院2012年2月～2016年3月收治的局部进展胰腺癌患者80例的临床资料，依据治疗措施不同进行分组，治疗A组（吉他西滨治疗）30例，治疗B组（5-氟尿嘧啶、吉西他滨治疗）50例。观察两组患者治疗前后体能量表评分、疼痛指数评分、总体幸福感评估量表评分、Spitzer生活质量指数评分情况，比较两组患者临床治疗缓解率情况。 结果 治疗后两组体能量表评分、疼痛指数评分均显著低于治疗前，总体幸福感评估量表评分、Spitzer生活质量指数评分均显著高于治疗前，差异均有统计学意义（P < 0.05）。治疗后治疗B组体能量表评分、疼痛指数评分均低于治疗A组，总体幸福感评估量表评分、Spitzer生活质量指数评分均高于治疗A组，差异均有统计学意义（P < 0.05）。治疗B组缓解率显著高于治疗A组，差异有统计学意义（P < 0.05）。 结论 5-氟尿嘧啶与吉西他滨联合同期放疗治疗局部进展胰腺癌患者可以明显改善患者体能、生活质量，降低疼痛程度，提高总体幸福感和临床疗效，值得推广应用。

[关键词] 5-氟尿嘧啶；吉西他滨；放疗；局部进展胰腺癌

[中图分类号] R735.902 [文献标识码] A [文章编号] 1673-7210（2017）05（b）-0084-04

[Abstract] Objective To investigate the clinical effect of 5-Fluorouracil and Gemcitabine combined with concurrent radiotherapy in the treatment of locally advanced pancreatic carcinoma. Methods The clinical data of 80 cases of patients with locally advanced pancreatic carcinoma admitted to Jianyang People's Hospital from February 2012 to March 2016 was analyzed retrospectively， they were divided into two groups by different treatment methods， treatment group A （Gemcitabine treatment） had 30 cases， treatment group B （5-Fluorouracil， Gemcitabine treatment） had 50 cases. The physical inventory score， pain index score， general well-being assessment scale， Spitzer life quality index score of two groups before and after treatment were observed， the remission rate of clinical treatment between the two groups was compared. Results The physical inventory score， pain index score of two groups after treatment were lower than those before treatment， the general well-being assessment scale score， Spitzer quality of life index score were higher than those before treatment， the differences were all statistically significant （P < 0.05）. After treatment， the physical inventory score and pain index score of treatment group B were lower than those of treatment group A， the general well-being assessment scale score and Spitzer quality of life index score were higher than those of treatment group A， the differences were all statistically significant （P < 0.05）. The remission rate of treatment group B was higher than that of treatment group A， the difference was statistically significant （P < 0.05）. Conclusion 5-Fluorouracil and Gemcitabine combined with concurrent radiotherapy in the treatment of locally advanced pancreatic carcinoma can improve the patients' physical inventory， quality of life， decrease the pain degree， increase general well-being assessment and clinical effect， which is worthy of promotion and application.

[Key words] 5-Fluorouracil； Gemcitabine； Radiotherapy； Locally advanced pancreatic carcinoma

胰腺癌早期的临床症状不是十分明显，随着病情的不断发展，患者一旦确诊就已经进入局部晚期或者已经出现转移[1-2]。手术治疗失去了最佳时机，临床常用的治疗方式是化疗联合放疗，其可以改善患者的临床症状，缓解病情的进一步发展，对于患者预后有一定的临床意义[3-4]。本研究通过对局部进展胰腺癌患者80例的临床资料进行分析，拟探讨5-氟尿嘧啶与吉西他滨联合同期放疗治疗局部进展胰腺癌的临床效果，现将结果汇报如下：

1 资料与方法

1.1 一般资料

回顾性分析四川省简阳市人民医院2012年2月～2016年3月收治的局部进展胰腺癌患者80例的临床资料，依据治疗措施的不同进行分组，治疗A组30例，男16例，女14例；……