齐拉西酮对强迫症增效治疗的临床研究

温琳+潘惟华

【摘要】目的：了解齐拉西酮在临床上对强迫症增效治疗的效果。方法：随机抽样我院近三年来收治的强迫症患者80例，将其均分两组，曲林组采用盐酸舍曲林药物进行治疗，齐拉西酮组患者在曲林组基础上加治齐拉西酮，对两组患者的治疗效果进行比较。结果：两组患者Y-BOCS比分在治疗前并未发现明显差异，而在治疗8周后，两组治疗评分相较治疗前均有显著提高，且齐拉西酮组患者治疗评分明显高于曲林组，差异具有统计学意义（P<0.05）；两组的不良反应症状量表于治疗后第二周、第四周、第八周测量患者服药后的不良反应状况中并未发现明显差异，80例患者也未发现服药不良情况；两组患者在为期8周的治疗过程中，齐拉西酮组患者有3例治愈，强迫症显著改善的患者有22例，强迫症有所改善的患者有10例，治疗无效的有5例；曲林组治愈患者有1例，强迫症显著改善患者有19例，强迫症有所改善的患者有11例，治疗无效的患者有9例；齐拉西酮组患者治疗总有效率高达87.5%，显著高于曲林组的77.5%。结论：临床在治疗强迫症患者过程中，在基础治疗上加齐拉西酮，可以达到增效治疗的目的，值得临床大力推广应用。

【关键词】齐拉西酮；盐酸舍曲林；强迫症

[Abstract] Objective：To understand ziprasidone is clinically for the treatment of obsessive-compulsive disorder synergistic effect.Methods： random sampling from 80 cases of ocd patients admitted in nearly three years，to divide two groups，QuLin group was treated with sertraline hydrochloride drugs，ziprasidone group of patients based on QuLin group cure ziprasidone，to compare the effect of two groups of patients.Results： two groups of patients - Y BOCS score before treatment did not find significant differences，and in 8 weeks after treatment，two groups of treatment scores were significantly increased，compared with before treatment，and patients score ziprasidone group was obviously higher than that of QuLin groups，statistically significant difference（P < 0.05）；Two groups of adverse symptoms scale in the second week，the fourth week，8 weeks after treatment measure patients after taking the drugs did not find significant differences in adverse conditions，80 patients also did not find drug adverse situation；Two groups of patients in the process of for eight weeks of treatment，patients with ziprasidone group 3 cases cured，obsessive-compulsive disorder patients improved significantly in 22 cases，10 cases of patients with obsessive-compulsive disorder improved，treatment of invalid in 5 cases；QuLin group to cure patients with 1 case，19 patients with obsessive-compulsive disorder significantly improve，obsessive-compulsive disorder patients improved in 11 cases，9 cases of invalid patients treated with；Ziprasidone group total effective rate up to 87.5%，treatment QuLin group is significantly higher than 77.5%.Conclusion： clinical in the process of treatment of patients with obsessive-compulsive disorder，plus ziprasidone in the treatment of foundation，can achieve the purpose of synergistic treatment，is worth the clinical promoted application.

【中圖分类号】R749 【文献标识码】A 【文章编号】2095-6851（2017）06-0-01

强迫症在心理治疗领域属于以强迫自我行为、具有强迫冲动、容易产生不可控的强迫观念为典型症状的精神领域病症[1]。强迫症患者在日常治疗过程中经过较长的治疗周期，仍然存在复发的可能性，并且在后期容易出现自我致残，所以临床对强迫症患者的治疗十分关注[2]。目前对强迫症患者使用药物治疗的有效率在41%到60%，治疗效果并不是十分理想，本次研究中，我院加治齐拉西酮作为增效药物，研究齐拉西酮对强迫症治疗的有效性和安全性。

1.基本资料与方法

1.1 基本资料

随机抽样我院近三年来收治的强迫症患者80例，其中有男性49例，女性31例，年龄分布在23到54岁，平均年龄为（33.1±2.9）岁；所有患者病程在12个月到20个月，平均病程为（14.1±1.2）个月；将其均分两组，曲林组采用盐酸舍曲林药物进行治疗，齐拉西酮组患者在曲林组基础上加治齐拉西酮；……