电位滴定法与手动滴定法测定药品含量的比较

梁永革　李丽

[摘要] 目的 对比电位滴定法与手动滴定法在测定药品含量方面的效果。方法 将我区医疗机构常用药物阿司匹林、盐酸左旋咪唑、氯化钠注射液作为研究对象，分别应用电位滴定法与手动滴定法对上述药品含量进行测定，并对不同检测方法下阿司匹林、盐酸左旋咪唑、氯化钠注射液三类药品的定量检测结果及相对标准偏差进行对比分析。结果 对比两种检测方法下的定量检测结果，电位滴定法下对阿司匹林、盐酸左旋咪唑、氯化钠注射液的检测结果与手动电位滴定法无明显差异（P>0.05）。两种检测方法下的相对标准偏差对比，电位滴定法下对阿司匹林、盐酸左旋咪唑、氯化钠注射液的相对标准偏差均显著低于手动滴定法，差异有统计学意义（P<0.05）。结论 电位滴定法对药品含量的检测结果准确可靠，相对标准偏差小，具有精密度高的优势，可逐步取代传统手动滴定法，并在药品含量检测分析领域中推广应用。

[关键词] 药品含量；电位滴定；手动滴定；定量检测

[中图分类号] R927.2 [文献标识码] B [文章编号] 1673-9701（2017）19-0040-03

[Abstract] Objective To compare the effect of potentiometric titration and manual titration on the determination of drug content. Methods Aspirin， levamisole hydrochloride and sodium chloride injection which were commonly used in our district were selected as the subjects. Potentiometric titration and manual titration were applied respectively for the determination of the contents of the above drugs. The quantitative analysis results and the relative standard deviations of the three types of drugs of aspirin， levamisole hydrochloride and sodium chloride injection were compared and analyzed under different determination methods. Results The quantitative determination results were compared under the two determination methods， and there was no significant difference between the determination results of aspirin， levamisole hydrochloride and sodium chloride injection under the potentiometric titration and manual titration methods， and the difference was not statistically significant （P>0.05）. The relative standard deviation was compared under the two determination methods， and the relative standard deviation of aspirin， levamisole hydrochloride and sodium chloride injection under the potentiometric titration was significantly lower than that under manual titration， and the difference was statistically significant（P<0.05）. Conclusion Potentiometric titration has an accurate and reliable result for the determination of drug contents. The relative standard deviation is small and the precision is high. It can gradually replace the traditional manual titration method and be promoted and applied in the field of determination and analysis of drug contents.

[Key words] Drug contents； Potentiometric titration； Manual titration； Quantitative determination

滴定分析是目前化學定量分析领域中应用最为广泛的技术手段之一[1-3]。在我国现行2015年版《中国药典》检验方法中，滴定分析所占比重大，且多以手动滴定法为主[4-6]。近年来，随着相关设备仪器技术性能的不断发展，电位滴定法在化学定量分析中的优势得到了大量临床研究与报道的证实[7-10]。为对比电位滴定法与手动滴定法在测定药品含量方面的效果，本研究将我区医疗机构常用药物阿司匹林、盐酸左旋咪唑、氯化钠注射液作为研究对象，分别应用上述两种滴定分析方法对药品含量进行检测，现报道如下。 ……