麝香保心丸联合阿托伐他汀治疗冠心病心绞痛临床研究

骆志鹏

[摘要] 目的 探讨麝香保心丸联合阿托伐他汀治疗冠心病心绞痛的临床疗效。方法 选取在2015年2月～ 2017年2月我院收治的114例冠心病心绞痛患者，按照随机数字表法将其平均分成观察组57例和对照组57例。给予对照组患者常规药物治疗，而观察组在对照组的基础上给予麝香保心丸联合阿托伐他汀治疗。比较两组的治疗总有效率及心电图变化。结果 观察组总有效率（94.74%）明显高于对照组（80.70%），差异具有统计学意义（χ2=5.211，P=0.022）；观察组心电图总有效率（86.96%）明显高于对照组（50.88%），差异有统计学意义（χ2=9.859，P=0.002）；在治疗过程中及治疗后，对照组有3例出现恶心、呕吐、反酸等不适症状，给予对症措施进行处理，症状消失；观察组未出现上述胃肠不适症状。结论 在常规药物治疗的基础上给予冠心病心绞痛患者麝香保心丸联合阿托伐他汀治疗，可显著提高治疗总有效率及心电图症状改善情况，减少胃肠不良反应的发生。

[关键词] 麝香保心丸；阿托伐他汀；冠心病；心绞痛

[中图分类号] R541.4 [文献标识码] A [文章编号] 2095-0616（2017）13-69-03

[Abstract] Objective To investigate the clinical efficacy of Shexiang Baoxin Pill Combined with atorvastatin in treatment of angina pectoris of coronary heart disease. Methods 114 patients with coronary heart disease in our hospital from February 2015 to February 2017 were randomly divided into observation group and control group according to random number table method， with 57 cases in each. The patients in control group were treated with routine medicine， while the patients in observation group were treated with Shexiang Baoxin Pill combined with atorvastatin treatment on the basis of the control group. The total effective rate and ECG changes of the two groups were compared. Results The total efficiency of the observation group （94.74%） was significantly higher than that of the control group （80.70%）， the difference was statistically significant （χ2=5.211， P=0.022）. The total effective rate of ECG in the observation group （86.96%） was significantly higher than that of the control group （50.88%）， the difference was statistically significant （χ2=9.859， P=0.002）. In the course of treatment and after treatment， there were 3 cases of nausea， vomiting， heartburn and other symptoms in control group. By taking timely measures to symptomatic treatment， symptoms disappeared. the observation group did not appear the symptoms of gastrointestinal discomfort. Conclusion For patients with angina pectoris of coronary heart disease， Shexiang Baoxin Pill combined with atorvastatin treatment on the basis of routine therapy can significantly improve the total efficiency of treatment and ECG improvement of symptoms， and reduce the incidence of gastrointestinal adverse reactions.

[Key words] Shexiang Baoxin pill； Atorvastatin； Coronary heart disease； Angina pectoris

冠心病心絞痛是老年人群中常见的心血管疾病，且多伴有糖尿病、高血压、高血脂等慢性病，其发病机制主要是由于机体血脂过高而引发动脉粥样硬化，或冠脉粥样斑块内出血、冠脉痉挛、血小板聚集血栓形成等因素，造成冠脉管腔变窄或冠脉分支堵塞，进而导致心肌缺氧、缺血。不仅对患者的生命造成威胁，还严重影响其生活质量[1-4]。因此，探索治疗冠心病心绞痛的有效药物疗法尤为重要。……