噻托溴铵联合沙丁胺醇治疗哮喘的临床疗效观察

沈焱+张永祥

[摘要] 目的 探讨分析噻托溴铵、沙丁胺醇联合应用治疗哮喘病症的临床效果。 方法 选取2012年5月～2015年4月在本院住院治疗的哮喘患者96例，随机分为甲、乙、丙三组各32例，甲组给予噻托溴铵，乙组给予沙丁胺醇，丙组联合应用噻托溴铵和沙丁胺醇，评估三组治疗效果。 结果 治疗后，三组患者肺功能均有所改善，各组治疗前后比较差异有统计学意义（P<0.05）。总有效率甲组为78.12%，乙组为75.00%，丙组为96.88%；总有效率丙组显著高于甲、乙组，与甲、乙组比较差异均具统计学意义（P<0.05）；甲组与乙组总有效率比较差异无统计学意义（P>0.05）。治疗后三组患者FEV1、FEV1/FVC、PEF均有改善，各组治疗前后比较差异有统计学意义（P<0.05）。三指标丙组显著高于甲、乙组，与甲、乙组比较差异均具统计学意义（P<0.05）；甲组与乙组三指标比较差异无统计学意义（P>0.05）。 结论 噻托溴铵与沙丁胺醇联合应用治疗哮喘疗效优于两者单独用药，值得临床推广。

[关键词] 噻托溴铵；沙丁胺醇；哮喘

[中图分类号] R473.5 [文献标识码] A [文章编号] 2095-0616（2017）13-72-03

[Abstract] Objective To explore the clinical effect of tiotropium bromide combined with salbutamol in the treatment of asthma. Methods 96 cases of asthma treated in our hospital from May 2012 to April 2015 were selected and randomly divided into group A，group B and group C with 32 cases in each.Patients in group A were treated with tiotropium bromide，patients in group B were treated with salbutamol，and patients in group C were treated with tiotropium bromide combined with salbutamol.Curative effects of the three groups were evaluated. Results After treatment，the pulmonary function of the three groups were improved，there was significant difference between the groups before and after treatment（P<0.05）.The total effective rate of group A was 78.12%，the group B was 75%，and the group C 96.88%.The total effective rate of group C was significantly higher than that of group B and group C，and the difference was statistically significant（P<0.05）.The total efficiency comparison of group A and group B showed no significant difference（P>0.05）.After treatment，the FEV1，FEV1/FVC，PEF of the three groups were improved，there was significant difference between the groups before and after treatment（P<0.05）.The three indexes of group C were significantly higher than those of group A and group B，and the differences of group C and group A，group B were statistically significant（P<0.05）.There were no statistical significances in group A and group B on the three index difference（P>0.05）. Conclusion Curative effect of tiotropium bromide combined with salbutamol in the treatment of asthma is better than the two drugs alone.It is worthy of promotion.

[Key words] Tiotropium bromide；Salbutamol；Asthma

支氣管哮喘（bronchial asthma）简称哮喘，是医学界公认四大顽症之一，是多种炎症细胞、介质及细胞因子参与介导共同作用而导致的一种常见的临床多发的呼吸道慢性炎症性疾病，本质为慢性非特异性气道炎症。近年来支气管哮喘发病率在全球范围内有逐年增加的趋势，临床上对于支气管哮喘的治疗仍以药物为主。为提高治疗效果，本研究以我院2012年5月～2015年4月收治的96例患者作为观察对象，具体观察噻托溴铵、沙丁胺醇以及两药联合应用临床治疗哮喘病症的疗效，现报道如下。

1 资料与方法

1.1 一般资料

参照2013年《中国支气管哮喘的防治指南（基层版）》中诊断标准[1]，对我院自2012 年5月～ 2015 年4月收治的哮喘患者进行筛选，遴选其中96例作为观察对象，经医院伦理委员会批准，患者签署知情同意书，随机分为甲、乙、丙三组，其中甲组32例，男18例，女14例，平均年龄（55.2±4.3）岁，平均病程（12.15±2.24）年。……