卡泊芬净治疗恶性血液病化疗后中性粒细胞缺乏合并深部真菌感染的临床观察

郑方英

[摘要]目的 分析卡泊芬净治疗恶性血液病化疗后中性粒细胞缺乏合并深部真菌感染的临床效果。方法 选取2013年12月～2015年11月本院收治的69例恶性血液病化疗后中性粒细胞缺乏合并深部真菌感染患者，按照入院先后顺序，分为实验组（37例）与对照组（32例）。对照组给予两性霉素B治疗，实验组给予卡泊芬净治疗。比较两组患者的治疗效果。结果 实验组的总有效率为86.5%，对照组为81.2%，组间差异无统计学意义（P>0.05）。实验组的总不良反应发生率为8.1%，明显低于对照组的21.8%，差异有统计学意义（P<0.05）。结论 恶性血液病化疗后中性粒细胞缺乏合并深部真菌感染，早期接受卡泊芬净治疗，可取得满意效果，不良反应少，具有推广价值。

[关键词]卡泊芬净；恶性血液病；中性粒细胞缺乏；深部真菌感染

[中图分类号] R559 [文献标识码] A [文章编号] 1674-4721（2017）07（a）-0027-03

Clinical observation of Caspofungin treating neutrophil deficiency combined with deep fungal infection after chemotherapy used for malignant hematologic disease

ZHENG Fang-ying

Department of Hematology，the First People′s Hospital of Huizhou City in Guangdong Province，Huizhou 516000，China

[Abstract]Objective To analyze the clinical effect of Caspofungin treating neutrophil deficiency combined with deep fungal infection after chemotherapy used for malignant hematologic disease.Methods 69 patients with neutrophil deficiency combined with deep fungal infection after chemotherapy used for malignant hematologic disease treated in our hospital from December 2013 to November 2015 were selected and they were divided into experimental group （37 cases） and control group （32 cases） according to order of admission.Control group was treated with Amphotericin B，while experimental group was treated with Caspofungin.The therapeutic effect between the two groups was compared.Results the total effective rate was 86.5% in experimental group and it was 81.2% in control group，and there was no significant difference between the two groups （P>0.05）.The total incidence rate of adverse reaction of experimental group was 8.1%，which was significantly lower than that of the control group （21.8%），and the difference was statistically significant （P<0.05）.Conclusion Caspofungin received in early stage treating neutrophil deficiency combined with deep fungal infection after chemotherapy used for malignant hematologic disease can obtain satisfactory effect，and adverse reaction is few，and it has the value of popularization.

[Key words]Caspofungin；Hematologic malignancies；Neutrophil deficiency；Deep fungal infection

恶性血液病，经化疗，中性粒细胞有所减少，抑制了机体免疫系统功能，易诱发真菌感染，就深部真菌感染而言，无明显病灶，体温升高异常，广谱抗生素治疗效果欠佳，严重时，可造成患者死亡，因此，临床医师十分关注该病的诊治。近几年，在医疗改革的推动下，临床医疗水平不断提升，诸多新研制的药物在临床上得到广泛应用，提高了疾病治疗效果[1]。其中，包括卡泊芬净。基于此，本院以69例患者为对象，经不同方式治疗，旨在分析卡泊芬净治疗恶性血液病化疗后中性粒细胞缺乏合并深部真菌感染的效果，现报道如下。

1资料与方法

1.1一般資料

以本院于2013年12月～2015年11月收治的69例恶性血液病化疗后中性粒细胞缺乏合并深部真菌感染患者为研究对象，按照入院先后顺序，分为实验组（37例）与对照组（32例）。本……