铋剂四联与传统三联疗法治疗幽门螺杆菌阳性小儿胃炎的比较

唐小军+刘婷

[摘要]目的 比较铋剂四联与传统三联疗法治疗幽门螺杆菌阳性小儿胃炎的临床效果。方法 选取2015年9月～2016年9月在我院进行幽门螺杆菌阳性小儿胃炎的80例患者，随机分成观察组和对照组，每组40例。对照组患者采用三联疗法，观察组患者采用铋剂四联疗法。利用14C-尿素呼气实验分析幽门螺杆菌的根除率，比较两组的治疗效果。结果 观察组患者的总有效率为90%，明显高于对照组的75%，幽门螺杆菌清除率为92.5%，明显高于对照组的77.5%，不良反应发生率为5%，明显低于对照组的15%，差异均有统计学意义（P<0.05）。结论 铋剂四联疗法治疗幽门螺杆菌阳性小儿胃炎的效果更好。

[关键词]小儿胃炎；14C-尿素呼气实验；幽门螺杆菌

[中图分类号] R725.7 [文献标识码] A [文章编号] 1674-4721（2017）07（c）-0078-03

Comparison of Bismuth quadruple and traditional triple therapy in the treatment of pediatric gastritis with positive Helicobacter pylori

TANG Xiao-jun1 LIU Ting2

1.Department of Pediatrics，Ji′an Hospital of Shanghai Dongfang Hospital in Jiangxi Province，Ji′an 343000，China；2.Department of Ophthalmology and Otorhinolaryngology，People′s Hospital of Ji′an County in Jiangxi Province，Ji′an 343000，China

[Abstract]Objective To compare the clinical effect of Bismuth quadruple and traditional triple therapy in the treatment of pediatric gastritis with positive Helicobacter pylori.Methods Eighty pediatric patients with gastritis of positive Helicobacter pylori from September 2015 to September 2016 treated in our hospital were selected and were randomly divided into the observation group and control group，and there were 40 cases in each group.Patients in the control group were treated with triple therapy，and in the observation group，patients were provided with Bismuth quadruple therapy.The eradication rate of Helicobacter pylori was analyzed using 14C-urea breath test.Results The total effective rate was 90% in the observation group，which was much higher than that in the control group （75%），and in the observation group，the eradication rate of Helicobacter pylori was 92.5%，which was higher than that in the control group （77.5%），and at the same time，the incidence rate of adverse reactions was 5%，which was greatly lower than that in the control group （15%），which were all displayed statistical difference （P<0.05）.Conclusion Bismuth quadruple and traditional triple therapy in the treatment of pediatric gastritis with positive Helicobacter pylori can obtain a better effect.

[Key words]Pediatric gastritis；14C-urea breath test；Helicobacter pylori

小儿胃炎是儿科消化系统的常见病，其发病率高、发病急、病情发展速度快，一旦没有获得及时治疗很容易导致儿童产生严重的脱水和電解质紊乱，严重时还会出现休克。小儿胃炎的临床表现为腹痛，急性胃炎中还会伴随发热和呕吐，慢性胃炎则可能伴随肚脐周围和腹部长期的间歇性疼痛。引起小儿胃炎的原因有十二指肠液反流、不健康的饮食习惯、化学药物的影响以及细菌和病毒感染等[1]。其中幽门螺杆菌（H. pylori）感染是主要诱因。幽门螺杆菌通常繁殖于胃上皮细胞表面黏液层，是革兰阴性小杆菌的一种，多呈现为螺旋状。大量临床事实证明，幽门螺杆菌与胃炎的关系十分密切，由幽门杆菌感染引发的胃炎和十二指肠溃疡的概率高达90%以上。流行病学资料相关数据表明，儿童是最容易感染幽门螺杆菌的人群。……