中西医结合治疗冠心病急性心肌梗死患者的临床疗效及安全性

单霞++苟彩霞++胡克峰

DOI：10.16662/j.cnki.1674-0742.2017.16.001

[摘要] 目的 對比研究中西医结合治疗冠心病急性心肌梗死（AMI）的临床疗效及安全性。方法 方便选取青岛市城阳区第二人民医院神经内科2015年10月—2016年10月收治92例冠心病AMI患者，根据随机数字表法均分为两组，对照组46例给予西药常规治疗，观察组46例加以自拟中药汤剂治疗，对比两组治疗后的临床疗效，记录患者治疗前后的DBP、SBP、LVEF、HR、WBC、CRP，并统计不良反应发生情况。结果 观察组治疗总有效率为95.65%，较对照组的80.43%显著提高（P<0.05）；观察组治疗后的DBP、SBP、HR分别为（78.55±9.32）mmHg、（129.16±8.19）mmHg、（74.15±8.76）次/min，与对照组比较差异无统计学意义（P>0.05）；观察组治疗后的LVEF为（0.68±0.03）%，显著高于对照组（P<0.05）；观察组治疗后的WBC、CRP水平分别为（6.15±1.32）×109/L、（8.516±1.19）mg/L，均较对照组显著降低（P<0.05）；观察组不良反应发生率为8.70%，与对照组的13.04%比较差异无统计学意义（P>0.05）。 结论 中西医结合治疗冠心病AMI疗效确切，较常规西药而言，可显著提高临床疗效，用药安全。

[关键词] 急性心肌梗死；冠心病；中西医结合；安全性

[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）06（a）-0001-03

Clinical Curative Effect and Safety of Combined Treatment of Traditional Chinese Medicine and Western Medicine of Patients with Acute Myocardial Infarction

SHAN Xia1， GOU Cai-xia1， HU Ke-feng2

1.Department of Neurology， Chengyang District Second Peoples Hospital， Qingdao， Shandong Province， 266112 China；2.Department of Orthopedics， Chengyang District Third Peoples Hospital， Qingdao， Shandong Province， 266112 China

[Abstract] Objective To compare and research the clinical curative effect and safety of combined treatment of traditional Chinese medicine and western medicine of patients with acute myocardial infarction. Methods 92 cases of AMI patients in our hospital from October 2015 to October 2016 were selected and randomly divided into two groups with 46 cases in each， the control group adopted the routine western medicine， while the observation group added the self-made TCM decoction， and the clinical curative effect was compared between the two groups， and the DBP， SBP， LVEF，HR， WBC，CRP before and after treatment were recorded and the occurrence of adverse reactions was counted. Results The total treatment effective rate in the observation group was obviously increased compared with that in the control group， （95.65% vs 80.43%）（P<0.05）， and the DBP，SBP，HR in the observation group after treatment were respectively （78.55±9.32）mmHg，（129.16±8.19）mmHg，（74.15±8.76）times/min， and there were no obvious differences between the two groups（P>0.05）， after treatment， the LVEF in the observation group was（0.68±0.03）%， which was obviously higher than that in the control group（P<0.05）， after treatment， the WBC，CRP levels in the observation group were respectively（6.15±1.32）×109/L，（8.516±1.19）mg/L， which were obviously reduced compared with those in the control group（P<0.05）， and the difference in the incidence rate of adverse reactions between the observation group and the control group was not obvious（8.70% vs 13.04%）（P>0.05）. Conclusion The curative effect of combined treatment of traditional Chinese medicine and western medicine of patients with acute myocardial infarction is definite， which can obviously improve the clinical curative effect compared with the routine western medicine， and the medication is safe.

[Key words] Acute myocardial infarction； Coronary heart disease； Combined treatment of traditional Chinese medicine and western medicine； Safety

冠心病为一种严重威胁患者生命的心血管疾病，在老年群体中的发病率较高，且随着我国老龄化进程的加快，其发病率也有呈上升趋势。急性心肌梗死（AMI）为冠状动脉病变基础上造成的冠状动脉急剧减弱[1]。西药常规治疗效果不太理想，且长期服用西药会增加不良反应发生率。研究指出，给予冠心病AMI患者中西医结合治疗，可显著提高临床疗效[2]。该研究纳入该院2015年10月—2016年10月收治的92例冠心病AMI患者作为研究对象，给予自拟中药汤剂联合西药治疗，观察其临床疗效和安全性，为临床冠心病AMI的治疗提供参考，现报道如下。……