中性粒细胞明胶酶相关脂质运载蛋白在肺癌性胸腔积液的变化情况

黄琪述　梁景强　陈锦华

【摘要】 目的 探讨中性粒细胞明胶酶相关脂质运载蛋白（NGAL）在肺癌性胸腔积液的变化情况， 分析其对恶性胸腔积液的诊断价值。方法 64例肺癌伴胸腔积液患者作为肺癌组， 60例良性胸腔积液患者作为良性组。比较两组胸腔积液中NGAL水平及肺癌组不同病理特征肺癌患者胸腔积液NGAL水平的差异。结果 肺癌组患者胸腔积液NGAL水平（61.84±10.59）ng/ml高于良性组患者的（48.32±

8.11）ng/ml， 差异有统计学意义（P<0.05）。胸腔积液NGAL水平与肺癌病理类型无关（P>0.05）；肿瘤直径越大， 淋巴结转移越多， 分化程度越低的患者， 其胸腔积液中NGAL水平越高， 差异有统计学意义（P<0.05）。结论 肺癌性胸腔积液中NGAL水平显著高于良性胸腔积液， 并且其水平与肿瘤大小、分化程度及淋巴结转移情况相关， 可作为恶性胸腔积液的判断指标， 并用于评价肺癌恶性程度。

【关键词】 中性粒细胞明胶酶相关脂质运载蛋白；肺癌；胸腔积液

DOI：10.14163/j.cnki.11-5547/r.2017.21.008

Changes of neutrophil gelatinase-associated lipocalin in pleural effusion of lung cancer HUANG Qi-shu， LIANG Jing-qiang， CHEN Jin-hua. Dongguan Wangniudun Hospital， Dongguan 523200， China

【Abstract】 Objective To investigate the changes of neutrophil gelatinase-associated lipocalin （NGAL） in pleural effusion of lung cancer， and analyze its diagnostic value for malignant pleural effusion. Methods There were 64 patients with lung benign and pleural effusion as lung cancer group， and 60 patients with with benign pleural effusion as benign group. Comparison were made on NGAL level in pleural effusion between two groups and difference of NGAL levels in pleural effusion of lung cancer patients with different pathological features. Results The lung cancer group had higher NGAL level in pleural effusion as （61.84±10.59） ng/ml than （48.32±8.11） ng/ml in the benign group， and the difference had statistical significance （P<0.05）. NGAL level in pleural effusion was not correlated with pathological types of lung cancer （P>0.05）. Patients with larger diameter of the tumor， more lymph node metastasis and lower degree of differentiation had higher the level of NGAL in the pleural effusion， and the difference had statistical significance （P<0.05）. Conclusion The level of NGAL in pleural effusion of lung cancer was significantly higher than that of benign pleural effusion， and its level was correlated with tumor size， differentiation degree and lymph node metastasis. So it could be used as an indicator evaluating the degree of malignancy of lung cancer.

【Key words】 Neutrophil gelatinase-associated lipocalin； Lung cancer； Pleural effusion

據全球癌症统计数据显示， 肺癌的发病率及死亡率在男性所患所有恶性肿瘤中均位第一， 在女性当中发病率位居第三， 死亡率仅次于乳腺癌位居第二位[1]， 在我国， 不论男女， 肺癌的死亡率已成为各类恶性肿瘤之首， 严重威胁着人类的生命健康[2]。胸腔积液是晚期肺癌的一个常见的临床表现， 其良恶性的判断与肺癌治疗、预后密切相关。中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinase-associated lipocalin， NGAL）是载脂蛋白家族成员， 与肿瘤的发生、发展密切相关[3]。本研究旨在探索NGAL在肺癌性胸腔积液的变化情况， 以分析其对恶性胸腔积液的诊断价值及与肺癌生物学行为间的关系， 现报告如下。