中老年健康体检者常见肿瘤标志物检测分析

严蓓蓓

DOI：10.16662/j.cnki.1674-0742.2017.23.017

[摘要] 目的 探讨中老年健康体检者常见肿瘤标志物（TM）检测价值。 方法 方便选择2016年1—12月期间在该院进行健康体检者3 980名作为该次研究对象，男性检测前列腺特异性抗原（PSA）、甲胎蛋白（AFP）、癌胚抗原（CEA）、糖类癌抗原（CA）199，女性检测CA199、CA125、AFP、CEA。对比分析TM诊断价值。 结果3 980名受检者中共检出198例阳性。其中男性2 145名，共检出169例阳性，女性1 835名，共檢出29例阳性，男性阳性检出率明显高于女性，差异有统计学意义（P<0.05）；男女两组AFP、CA199、CA125相比，差异无统计学意义（P>0.05）；男女CEA水平相比，男性组（2.9±1.1）ng/mL高于女性组（1.8±0.9）ng/mL，差异有统计学意义（P<0.05）。男性>59岁CA199（3.4±1.9）U/mL、CA125（4.8±2.4）U/mL与PSA（0.8±0.7）U/mL水平显著高于≤59岁[（2.1±1.2）、（2.5±1.5）、（0.3±0.2）U/mL]，差异有统计学意义（P<0.05）；女性>59岁CA125（4.7±1.9）U/mL、CEA（1.9±0.9）ng/mL水平显著高于≤59岁[（3.2±1.4）U/mL、（1.4±0.6）ng/mL]，差异有统计学意义（P<0.05）。 结论 中老年健康体检者进行常见肿瘤标志物筛查有利于提前发现早期肿瘤，减少漏诊，为后期治疗提供依据。

[关键词] 中老年；肿瘤标志物；健康体检

[中图分类号] R194 [文献标识码] A [文章编号] 1674-0742（2017）08（b）-0017-03

Detection and Analysis of Common Tumor Markers in Middle-aged and Elderly Health Examinations

YAN Bei-bei

Department of Laboratory， the Fourth Peoples Hospital of Taizhou， Taizhou， Jiangsu Province，225300 China

[Abstracts] Objective This paper tries to investigate the detection value of common tumor markers in middle-aged and elderly health examinations. Methods Convenient selection a total of 3 980 healthy subjects received in this hospital from January to December 2016 were selected. Male patients were tested for prostate specific antigen（PSA）， alpha-fetoprotein （AFP）， carcinoembryonic antigen（CEA）， carbohydrate Cancer antigen（CA） 199； female patients were tested for CA199， CA125， AFP， and CEA. TM diagnostic value was compared. Results A total of 198 cases were detected positive in 3 980 cases， 169 cases were detected positive among the 2 145 male patients and 29 cases were detected positive among the 1 835 cases of female patients， so the positive rate was of male patients was higher than that of the female patients， the difference was significant （P<0.05）； there was no significant difference in AFP， CA199， CA125 among the male and female patients（P>0.05）； the CEA level of the male patients was （2.9±1.1）ng/mL， higher than that of the female group of （1.8±0.9）ng/mL， the difference was significant（P<0.05）； CA199， CA125 and PSA of male patients whose age was above 59 were（3.4±1.9）， （4.8±2.4） and （0.8±0.7）U/mL respectively， higher than those less than or equal to 59 years old of （2.1±1.2）， （2.5±1.5）， （0.3±0.2）U/mL， the difference was significant（P<0.05）. CA125 and CEA of female patients whose age was above 59 were （4.7±1.9）U/mL and （1.9±0.9） ng/mL， higher than that below or equal to 59 years old of （3.2±1.4）U/mL and （1.4±0.6）ng/mL， the difference was statistically significant（P<0.05）. Conclusion The screening of common tumor markers in middle-aged and old healthy subjects is helpful for early detection of early tumors， reducing missed diagnosis， and providing basis for post-treatment.endprint

[Key words] Middle-aged and elderly； Tumor markers； Healthy physical examination

随着环境污染的加重以及人口老龄化的加剧，恶性肿瘤的发病率也随之不断升高，尽早诊断、尽早治疗是治疗的关键，以提高患者的生存率与生存质量[1-2]。TM检测效果显著优于CT、PET-CT、MRI等物理检查，可在物理检测发现肿瘤之前提前检出，所取得的成果较为理想[3-4]。该研究旨在分析2016年1—12月于该院进行健康体检的3 980名中老年人肿瘤标志物的检测结果，探讨常见肿瘤标志物在老年健康体检肿瘤筛查中的作用，現报道如下。

1 资料与方法

1.1 一般资料

方便选择该院进行健康体检人员3 980名作为该次研究对象，其中男2 145名，女1 835名；年龄40～82岁，平均（64.26±4.37）岁。男性检测PSA、AFP、CEA、CA199，女性检测CA199、CA125、AFP、CEA。

1.2 方法

抽取所有受检者3 mL空腹静脉血，离心后检测，检测仪器为郑州安图实验仪器有限公司生产的LUMO，试剂为配套试剂，所有肿瘤标志物均采用化学发光法测定，检测过程中的各项操作均需严格按照产品说明书进行。……