二甲双胍联合胰岛素治疗小儿糖尿病的临床效果分析

赵静

[摘要] 目的 探讨二甲双胍联合甘精胰岛素治疗小儿糖尿病的临床效果。方法 选取2016年1—12月该院收治的100例糖尿病患儿随机分为两组（对照组和观察组），对照组患儿予以甘精胰岛素治疗，观察组患儿在此基础上加用二甲双胍片口服，并比较两组患儿治疗前后血糖、血脂改善情况以及不良反应发生率。结果 治疗后观察组患儿空腹血糖、餐后2 h血糖、糖化血红蛋白、TG、LDL-C和HDL-C等指标明显优于对照组患儿（P<0.05）；观察组患儿不良反应发生率高于对照组患儿，但两者比较差异无统计学意义（P>0.05）。 结论 与单用甘精胰岛素相比，甘精胰岛素联合二甲双胍在改善糖尿病患儿血脂和血糖水平方面更有优势，其值得推广借鉴。

[关键词] 甘精胰岛素；二甲双胍；糖尿病；儿童；临床效果

[中图分类号] R587.1 [文献标识码] A [文章编号] 1672-4062（2017）05（b）-0001-02

[Abstracts] Objective This paper tries to investigate the clinical effect of metformin combined with insulin in the treatment of children with diabetes mellitus. Methods A total of 100 children with diabetes mellitus from January to December 2016 treated in this hospital were selected and randomly divided into two groups （the control group and the observation group）， the patients in the control group were treated with insulin glargine and the patients in the observation group added metformin tablets， and the blood glucose， blood lipid and the incidence of adverse reactions before and after treatment of the two groups were compared. Results The levels of blood glucose， glycosylated hemoglobin， TG， LDL-C and HDL-C in the observation group were significantly better than that in the control group （P<0.05）. The incidence of adverse reactions in the observation group was higher than that in the control group， there was no significant difference between the two groups （P>0.05）. Conclusion Compared with insulin treatment alone， insulin glargine combined with metformin in improving the blood lipid and blood glucose levels in children is more effective， so it is worth reference.

[Key words] Insulin glargine； Metformin； Diabetes mellitus； Children； Clinical effect

近幾年来，随着环境因素和饮食习惯的改变，糖尿病疾病的发生率不断增加，同时患病人群越来越低龄化，特别是儿童人群而言，糖尿病对其生长发育带来严重影响。文献报道，对糖尿病患儿采取规范化降血糖治疗能有效维持其血糖平稳，减少并发症的发生，以及延缓病情的进一步发展[1]。甘精胰岛素是一种长效胰岛素，其药物作用时间持久，能在24 h内起到降血糖的效果。二甲双胍属于双胍类降糖药物，能有效抑制肝糖原的异生，加速葡萄糖无氧降解，减少肝糖原输出，提高机体对胰岛素敏感性。该研究选取该院2016年1—12月收治的100例患儿为研究对象，对二甲双胍联合甘精胰岛素治疗小儿糖尿病的临床效果进行探讨，旨在为临床治疗儿童糖尿病提供参考依据，现报道如下。……