动态检测PCT与hs—CRP在全身和局部细菌感染性疾病诊断中的临床研究

王颖

【摘要】 目的：研究与观察动态检测PCT与hs-CRP在全身和局部细菌感染性疾病诊断中的临床作用。方法：选取2015年6月-2016年11月本院的诊治的56例全身细菌感染患者为A组，56例局部细菌感染者为B组，56名健康者为C组，比较A、B组治疗前和治疗后12 h、1 d、3 d、5 d及7 d时和C组的血清PCT与hs-CRP水平与阳性率。结果：A组、B组治疗前和治疗后12 h、1 d、3 d、5 d及7 d的血清PCT与hs-CRP水平与阳性率均高于C组，且A组的血清PCT与hs-CRP水平与阳性率均高于B组，A组与B组治疗后的血清PCT与hs-CRP水平与阳性率均持续降低，治疗后1、3、5及7 d的血清水平与阳性率均低于治疗前和治疗后12 h，差异均有统计学意义（P<0.05）。结论：PCT与hs-CRP在全身和局部细菌感染性疾病的诊断与区别中具有较高的价值，且其动态变化对于疾病的发展转归与治疗指导有积极的临床意义。

【关键词】 动态检测； PCT； hs-CRP； 全身细菌感染； 局部细菌感染

【Abstract】 Objective：To study and observe the clinical role of PCT and hs-CRP dynamic detection in the diagnosis of systemic and local bacterial infectious diseases.Method：From June 2015 to November 2016，56 patients with systemic bacterial infection in our hospital were selected as the group A，56 patients with local bacterial infection were selected as the group B，56 healthy persons were selected as group C，then the serum PCT and hs-CRP levels and positive rates of group A and group B before the treatment and at 12 hours，1st，3rd，5th and 7th day after the treatment and group C were compared.Result：The serum PCT and hs-CRP levels and positive rates of group A and group B before the treatment and at 12 hours，1st，3rd，5th and 7th day after the treatment were all higher than those of group C，the serum PCT and hs-CRP levels and positive rates of group A were all higher than those of group B，the serum PCT and hs-CRP levels and positive rates of group A and group B all continuously decreased，and the serum levels and positive rates at 1st，3rd，5th and 7th day after the treatment were all lower than those before the treatment and at 12 hours after the treatment，the differences were statistically significant（P<0.05）.Conclusion： Dynamic detection of PCT and hs-CRP has high value in diagnosis and differentiation of systemic and local bacterial infectious diseases，which also has positive clinical significance for guide disease development and treatment.

【Key words】 Dynamic detection； PCT； hs-CRP； Systemic bacterial infectious diseases； Local bacterial infectious diseases

First-authors address：Traditional Chinese Medicine Hospital of Qionglai City，Qionglai 611530，China

doi：10.3969/j.issn.1674-4985.2017.25.015

細菌感染性疾病是由细菌感染导致的疾病，当机体抵抗力降低时，免疫防御功能功能变差，病原菌侵入机体，导致感染的发生，而此类感染可分为全身与局部感染，对患者机体的影响部位与影响程度也存在一定差异[1]。同时感染可导致患者的炎性相关指标应激性变化，对于此类指标的研究与掌握是对感染存在与否及严重程度的必要基础。临床中对于感染具有较高敏感度的指标较多，其中hs-CRP作为临床常见的一类急性时相反应蛋白，其在各类感染患者中的异常表达程度较高，而近年来临床中关于PCT的研究不断增多，较多研究认为PCT在感染反应中的敏感度甚至高于hs-CRP[2-3]。动态检测PCT与hs-CRP是更为有效地反映机体感染状态实时变化的方式，对于感染的诊断与治疗有积极的临床意义。因此，本研究中笔者就动态检测PCT与hs-CRP在全身和局部细菌感染性疾病诊断中的临床作用进行研究，现报道如下。……