琥珀酸美托洛尔缓释片联合瑞舒伐他汀钙治疗慢性心力衰竭60例疗效分析

胡岚

[摘要] 目的 研究慢性心力衰竭患者采取琥珀酸美托洛尔缓释片结合瑞舒伐他汀治疗的临床效果。 方法 选择我院2015年3月～2016年9月收治的60例慢性心力衰竭患者作为研究对象，按照随机数字表法分为研究组与对照组各30例，研究组采取琥珀酸美托洛尔缓释片联合瑞舒伐他汀钙，对照组采取琥珀酸美托洛尔缓释片，比较两组患者治疗效果。 结果 经过观察临床效果看出，治疗前两组患者各项指标水平均无明显差别（t=-0.356，0.609，0.250，-1.198，-0.235，0.352，P>0.05），治疗后发现研究组心率、LVEDD水平低于对照组，但LVEF水平高于对照组（t=-3.402，2.160，-3.725，P<0.05）；且NT-ProBNP、TC以及LDL-C水平均比对照组低（t=-7.796，-2.013，-2.138，P<0.05）；两组患者不良反应发生率无明显差别，差异无统計学意义（χ2=1.925，P>0.05）。 结论 慢性心力衰竭患者采取琥珀酸美托洛尔缓释片结合瑞舒伐他汀钙治疗效果显著，明显改善患者心功能，安全性较高，提高患者生存质量。

[关键词] 疗效分析；琥珀酸美托洛尔缓释片；瑞舒伐他汀钙；慢性心力衰竭；

[中图分类号] R541.7 [文献标识码] A [文章编号] 2095-0616（2017）20-60-03

Clinical analysis of metoprolol succinate sustained-release tablets combined with rosuvastatin calcium in treatment of chronic heart failure in 60 cases

HU Lan

Geriatric Ward of Huizhou Central People's Hospital，Huizhou 516001，China

[Abstract] Objective To study the clinical effect of Metoprolol Succinate Sustained-release Tablets combined with rosuvastatin in treatment of chronic heart failure. Methods 60 patients with chronic heart failure who were treated in our hospital from March 2015 to September-2016 were selected as the subjects and divided into the study group and the control group with 30 cases each according to the random number method.The study group was treated with Metoprolol Succinate Sustained-release Tablets combined with rosuvastatin calcium，and the control group was treated with Metoprolol Succinate Sustained-release Tablets.The therapeutic effects of the two groups were compared. Results The clinical effect showed that，Before treatment， there were no significant differences between the two groups （t=-0.356，0.609，0.250，-1.198，-0.235，0.352，P>0.05），after treatment，the heart rate and LVEDD levels of the study group were lower than that of the control group，but the level of LVEF was higher than that of the control group （t=-3.402，2.160，-3.725，P<0.05）；The levels of NT-ProBNP，TC and LDL-C were lower than those of the control group （t=-7.796，-2.013，-2.138， P<0.05）；There was no significant difference in the incidence of adverse reactions between the two groups， and the results were not statistically significant （χ2=1.925，P>0.05）. Conclusion The effect of Metoprolol Succinate Sustained-release Tablets combined with rosuvastatin calcium in patients with chronic heart failure is significant，which can improve the heart function，security and the quality of life of patients.

[Key words] Curative effect analysis；Metoprolol Succinate Sustained-release Tablets；Rosuvastatin calcium；Chronic heart failureendprint

慢性心力衰竭屬于心内科常见疾病，属于心血管疾病终末阶段的主要因素。患者临床症状与心室或者心房受累有关，主要表现为呼吸困难、咳嗽、咯血以及全身乏力等，严重危害患者身心健康[1-2]。临床上治疗方式主要以利尿以及扩张血管为主，虽然取得过一定应用价值，但效果并不显著，如何选择疗效确切且安全性高的药物成为医疗界关注重点[3]。因此我院展开研究，探讨琥珀酸美托洛尔缓释片结合瑞舒伐他汀钙在慢性心力衰竭治疗中的应用价值，现将结果报道如下。

1 资料与方法

1.1 一般资料

选择我院2015年3月～2016年9月收治的60例慢性心力衰竭患者作为研究对象，按照随机数字表法分为研究组与对照组各30例。研究……