高原性肺动脉高压患者行泻肺化瘀法治疗对肺血管活性因子的影响

赵娅琳

[摘要] 目的 分析中医泻肺化瘀法在高原性肺动脉高压患者治疗中的应用价值。方法 随机选取该院2016年7月—2017年7月实施治疗的86例高原性肺动脉高压患者，依照患者的治疗方法分成两组，对照组和观察组患者各43例，分别实施单纯西医治疗及西医结合泻肺化瘀法治疗，对比分析两组患者肺血管活性因子变化。结果 治疗后，和对照组患者相比，观察组患者的IMD、ADM、ET-1、mPAP、CRP、IL-6、TNF-a、5-HT以及AT-II指标明显偏低，差异对比结果显示（t=8.634 1/9.637 3/10.286 7/8.274 6/10.324 6/12.159 6/8.569 3/9.539 6/8.123 9，P<0.05）。结论 在高原性肺动脉高压患者临床治疗中，对患者实施泻肺化瘀法治疗，有助于显著提升患者的临床治疗效果，改善患者肺血管活性因子，值得推广应用。

[关键词] 高原性肺动脉高压；泻肺化瘀法；肺血管活性因子

[中图分类号] R543 [文献标识码] A [文章编号] 1674-0742（2018）03（a）-0063-03

Effect of Xiepi Huayu Therapy on Pulmonary Vasoactive Factors in Patients with High Altitude Pulmonary Hypertension

ZHAO Ya-lin

Department of Respiratory Medicine， the First Peoples Hospital of Kunming， Kunming， Yunnan Province， 650000 China

[Abstract] Objective This paper tries to analyze the application of Chinese medicine purging lung and removing stasis method in the treatment of patients with high altitude pulmonary hypertension. Methods A total of 86 patients with high altitude pulmonary hypertension who were treated in this hospital from July 2016 to July 2017 were randomly selected and divided into two groups according to the patients treatment. The patients in the control group and observation group each received 43 cases of Western medicine combined with Xiefei Huayu treatment， comparative analysis of two groups of patients with pulmonary vascular activity factor changes was carried out. Results After treatment， the indexes of IMD， ADM， ET-1， mPAP， CRP， IL-6， TNF-a， 5-HT and AT-II in the observation group were significantly lower than those in the control group （t=8.634 1/9.637 3/10.286 7/8.274 6/10.324 6/12.159 6/8.569 3/9.539 6/8.123 9， P<0.05）. Conclusion In the clinical treatment of patients with high altitude pulmonary hypertension， the implementation of the method of purging the lung and removing blood stasis is helpful to significantly improve the clinical treatment effect of patients and improve the pulmonary vasoactive factors in patients， which is worthy of popularization and application.

[Key words] High altitude pulmonary hypertension； Purging lung and removing stasis； Pulmonary vasoactive factor

高原性肺動脉高压则为正常人在高原地区因为受到低压性缺氧影响，从而导致肺小动脉功能和器质性改变，最终发生肺动脉压力增高。早期高原性肺动脉高压则主要是因为急性缺氧所致肺小动脉收缩，慢性低氧的长期影响则会导致心室肌及肺血管重构，严重可以引发难治性梗阻性肺动脉高压，对患者身体健康及生命安全造成影响。中医在高压性肺动脉高压患者治疗中的应用，具有良好的临床效果。该文随机选取该院2016年7月—2017年7月实施治疗的86例高原性肺动脉高压患者作为研究对象，对中药泻肺化瘀法在高原性肺动脉高压患者的临床治疗效果观察，现报道如下。

1 资料与方法

1.1 一般资料

随机选取该院实施治疗的86例高原性肺动脉高压患者，依照患者的治疗方法分成两组，对照组和观察组患者各43例，其中对照组患者中男性26例、女性……