磷酸西格列汀治疗2型糖尿病的用药效果观察及研究

熊新锐　郑爱军

[摘要] 目的 观察及研究磷酸西格列汀治疗2型糖尿病的用药治疗效果。方法 选取2015年2月—2016年10月该院收治的86例2型糖尿病患者设作研究对象，随机将86例患者分成对照组与观察组，其中对照组43例患者仅应用二甲双胍治疗，余下43例为观察组在二甲双胍治疗基础上配合磷酸西格列汀治疗，对比2组血糖、糖化血红蛋白、胰岛素抵抗指数等情况。结果 治疗后，观察组空腹血糖、餐后2 血糖、糖化血红蛋白等指标明显优于对照组，2组对比差异有统计学意义（P<0.05）；2组胰岛素抵抗指数均有降低，2组对比差异无统计学意义（P>0.05）。结论 磷酸西格列汀治疗2型糖尿病效果较为理想，可以有效改善患者血糖和糖化血红蛋白等指标，值得推广应用。

[关键词] 磷酸西格列汀；2型糖尿病；用药效果；观察

[中图分类号] R59 [文献标识码] A [文章编号] 1672-4062（2018）02（a）-0054-02

Observation and Research on Medication Effect of Sitagliptin Phosphate in Treatment of Type 2 Diabetes

XIONG Xin-rui1， ZHENG Ai-jun2

1.Department of Internal Medicine， Macheng Muzidian Health Center， Macheng， Hubei Province， 438321 China；2.Department of Drug and Equipment， Macheng Muzidian Health Center， Macheng， Hubei Province， 438321 China

[Abstract] Objective To observe and research the effect of sitagliptin phosphate in treatment of type 2 diabetes. Methods 86 cases of patients with type 2 diabetes in our hospital from February 2015 to October 2016 were selected and randomly divided into two groups with 43 cases in each， the control group were treated with melbine， while the observation group were treated with melbine combined with sitagliptin phosphate， and the blood glucose， glycosylated hemoglobin and insulin resistance index were compared between the two groups. Results After treatment， the fasting blood glucose， postprandial 2 h blood glucose and glycosylated hemoglobin in the observation group were obviously better than those in the control group （P<0.05）， and the difference between groups was statistically significant， and the insulin resistance index of the two groups decreased， and the difference was not obvious（P>0.05）. Conclusion The effect of sitagliptin phosphate in treatment of type 2 diabetes is ideal， which can effectively improve the blood glucose and glycosylated hemoglobin， and it is worth promotion and application.

[Key words] Sitagliptin phosphate； Type 2 diabetes； Medication effect； Observation

隨着人们生活水平的提高，糖尿病发病率逐年上升，传统治疗方式会增加低血糖风险，甚至引起胃肠不良、水肿等不良反应，不能控制餐后高血糖情况[1]。临床选择不同口服药控制疾病，其中70%以上的患者并不能控制血糖[2]。该次研究中取2015年2月—2016年10月收治的86例2型糖尿病患者分成2组应用不同药物治疗进行对比研究，其中观察组在二甲双胍治疗同时联合磷酸西格列汀治疗对血糖控制效果更为理想，现报道如下。

1 资料与方法

1.1 一般资料

选取该院收治的86例2型糖尿病患者设作研究对象，所有均确诊为2型糖尿病，排除了合并严重肝肾功能疾病患者。所有患者和家属均在知情时签署了知情同意书，经医院伦理委员会批准，根据双盲法，随机将86例患者分成对照组与观察组，各43例。……