高频震荡通气联合硫酸镁与西地那非治疗新生儿持续性肺动脉高压临床疗效研究

林宁　林玉婵　江月明　封稚　杨少芬

【摘要】 目的：分析高频震荡通气联合硫酸镁与西地那非治疗新生儿持续性肺动脉高压的临床疗效。方法：2013年2月-2017年6月本院收治的新生儿持续性肺动脉高压患儿中选取88例，按照随机数字表法分为对照组与观察组，每组44例。两组患者均联合应用硫酸镁与西地那非治疗，并给予对照组患儿常频通气治疗，给予观察组患儿高频震荡通气治疗，对比两组临床疗效。结果：观察组住院时间、氧疗时间均短于对照组（P<0.05）。两组治疗后SBP、SPAP、SaO2、pH、OI、PaO2和PaCO2均优于治疗前（P<0.05），观察组改善幅度大于对照组（P<0.05）。结论：高频震荡通气、硫酸镁与西地那非联合治疗新生儿持续性肺动脉高压的临床疗效显著。

【关键词】 高频震荡通气； 西地那非； 硫酸镁； 新生儿； 持续性肺动脉高压

Clinical Efficacy of High Frequency Oscillatory Ventilation Combined with Magnesium Sulfate and Sildenafil in Treatment of Persistent Pulmonary Hypertension of Newborn/LIN Ning，LIN Yuchan，JIANG Yueming，et al.//Medical Innovation of China，2018，15（12）：052-054

【Abstract】 Objective：To analyze the clinical efficacy of high frequency oscillatory ventilation combined with Magnesium Sulfate and Sildenafil in the treatment of persistent pulmonary hypertension of newborn.Method：A total of 88 patients with persistent pulmonary hypertension of newborn treated in our hospital from February 2013 to June 2017 were randomly divided into control group and observation group according to the table of random numbers，44 cases in each group.Two groups were given Magnesium Sulfate and Sildenafil，the control group was treated with conventional ventilation therapy，and the observation group was treated with high frequency oscillation ventilation.The clinical curative effects of two groups were compared.Result：The duration of hospitalization and oxygen therapy in the observation group were shorter than those in the control group（P<0.05）.SBP，SPAP，SaO2，pH，OI，PaO2 and PaCO2 of two groups after treatment were all improved than those before treatment（P<0.05），and the improvement of the observation group was greater than that in the control group（P<0.05）.Conclusion：The clinical efficacy of high frequency oscillatory ventilation combined with Magnesium Sulfate and Sildenafil are effective in treating persistent pulmonary hypertension of newborn.

【Key words】 High frequency oscillatory ventilation； Sildenafil； Magnesium Sulfate； Newborn； Persistent pulmonary hypertension

First-authors address：The Second Peoples Hospital of Zhanjiang，Zhanjiang 524000，China

doi：10.3969/j.issn.1674-4985.2018.12.015

新生兒持续肺动脉高压指的是新生儿出生之后，肺循环阻力与压力出现持续性增高现象，促使其肺动脉压力相较于体循环动脉压力更高，新生儿出现发绀与持续性缺氧现象，严重情况下甚至会直接死亡，所以急需及时寻找一种有效方式对其进行治疗，以此来将新生儿死亡率降低[1-5]。为此，本研究在该疾病治疗中联合应用了高频震荡通气、硫酸镁与西地那非，并对其应用效果进行探究，现报道如下。

1 资料与方法

1.1 一般资料 88例新生儿持续性肺动脉高压患儿于2013年2月-2017年6月在本院接受治疗，按照随机数字表法分为对照组与观察组，每组44例。本研究获得医院伦理委员会批准，所有患儿家属均签署了知情同意书。纳入标准：依从性较高者；自愿参与者；对本研究中所用药物不存在应用禁忌证者。排除标准：临床状况不稳定者；先天性肺部疾病者；……