拉贝洛尔联合硫酸镁治疗重度妊娠期高血压疾病的效果分析

倪建枝

【摘要】 目的：探討重度妊娠期高血压疾病患者实施拉贝洛尔联合硫酸镁治疗的临床效果。方法：选择本院2015年1月-2017年1月收治的70例重度妊娠期高血压疾病患者实施观察研究，按患者治疗方案实施分组，分为常规组（n=35）和联合组（n=35）。常规组实施硫酸镁治疗，联合组实施拉贝洛尔联合硫酸镁治疗，对比分析不同治疗方案患者的治疗效果、临床表现、母婴结局、用药不良反应发生情况。结果：联合组患者的治疗总有效率为94.3%，高于常规组的77.1%，差异有统计学意义（字2=4.200，P=0.040）；联合组患者治疗后收缩压为（135.2±9.5）mm Hg、舒张压为（85.6±6.2）mm Hg、24 h蛋白尿水平为（1.8±0.6）g，均低于常规组的收缩压（146.5±10.7）mm Hg、舒张压（96.5±6.7）mm Hg、24 h蛋白尿水平（2.4±0.7）g，差异均有统计学意义（P<0.05）；联合组患者子痫、产后出血、胎盘早剥、胎儿窘迫、新生儿窒息、低体重儿发生率分别为2.9%、8.6%、0、2.9%、5.7%、5.7%，均低于常规组患者的20.0%、34.3%、17.1%、20.0%、25.7%、22.9%，差异均有统计学意义（P<0.05）。联合组患者用药不良反应发生率为11.4%，与常规组的17.1%比较，差异无统计学意义（字2=0.467，P=0.495）。结论：重度妊娠期高血压疾病患者实施拉贝洛尔联合硫酸镁治疗的临床效果显著，可改善母婴预后。

【关键词】 重度妊娠期高血压疾病； 拉贝洛尔； 硫酸镁； 妊娠结局

Analysis of the Effect of Labetalol Combined with Magnesium Sulfate for the Treatment of Severe Hypertensive Disorder Complicating Pregnancy/NI Jianzhi.//Medical Innovation of China，2018，15（12）：099-102

【Abstract】 Objective：To investigate the clinical effect of Labetalol combined with Magnesium Sulfate in patients with severe hypertensive disorder complicating pregnancy.Method：70 patients with severe hypertensive disorder complicating pregnancy in our hospital from January 2015 to January 2017 were selected to carry out an observation study，according to the treatment plan of patients，they were divided into routine group（n=35）and combination group（n=35）.The routine group was given Magnesium Sulfate，the combination group was treated with Labetalol combined with Magnesium Sulfate.The treatment effect，clinical manifestations，maternal and infant outcomes and the adverse drug reactions of the patients under different treatment regimens were compared and analyzed.Result：The total effective rate of the combination group was 94.3%，which was higher than 77.1% of the routine group，the difference was statistically significant（字2=4.200，P=0.040）；after treatment，systolic blood pressure was（135.2±9.5）mm Hg，diastolic was（85.6±6.2）mm Hg，and 24 h proteinuria level was（1.8±0.6）g in the combination group，which were lower than （146.5±10.7）mm Hg，（96.5±6.7）mm Hg and （2.4±0.7）g of the control group，the differences were statistically significant（P<0.05）.The incidences of eclampsia，postpartum hemorrhage，placental abruption，fetal distress，neonatal asphyxia and low birth weight in the combination group were 2.9%，8.6%，0，2.9%，5.7%，5.7% respectively，which were significantly lower than 20.0%，34.3%，17.1%，20.0%，25.7%，22.9% in the routine group，the differences were statistically significant（P<0.05）.The incidence of adverse drug reactions in the combined group was 11.4%，compared with 17.1% in the routine group，the difference was not statistically significant（字2=0.467，P=0.495）.Conclusion：The clinical effect of Labetalol combined with Magnesium Sulfate in patients with severe hypertensive disorder complicating pregnancy is significant，which can improve the prognosis of maternal and infant.

【Key words】 Severe hypertensive disorder complicating pregnancy； Labetalol； Magnesium Sulfate； Pregnancy outcome

First-authors address：Huaian Maternal and Child Health Care Hospital，Huaian 223001，China

doi：10.3969/j.issn.1674-4985.2018.12.028

妊娠期高血压疾病是妊娠期特发疾病，包括妊娠期高血压、子痫前期、子痫、慢性高血压并发子痫前期、慢性高血压五种类型。当前妊娠期高血压疾病已经成为妊娠期最为常发的严重并发症之一，且临床报道妊娠期高血压疾病临床发生率可达7%～12%[1]。妊娠期高血压疾病常导致患者出现水肿、高血压、蛋白尿等症状，重度患者常出现抽搐、昏迷症状，严重影响母婴安全，是导致孕产妇及围生儿死亡的重要原因。及时控制患者血压水平，并减少动脉痉挛导致的抽搐、昏迷症状是临床治疗妊娠期高血压疾病的主要方案。拉贝洛尔和硫酸镁均是当前临床治疗妊娠期高血压疾病的常用药物，均具有一定治疗效果[2]。……