SLE合并静脉血栓栓塞性疾病的高危因素、临床特点及其预防研究

何俊锋

[摘要] 目的 研究SLE合并静脉血栓栓塞性疾病的高危因素、临床特点及其预防措施。方法 方便选取该院2014年7月—2017年7月收治的40例SLE合并静脉血栓栓塞性疾病患者的临床资料进行回顾性分析，将这些患者作为血栓组，将该院同期收治的40例SLE未合并静脉血栓栓塞性疾病患者作为对照组，对两组患者的临床资料、实验室指标进行观察和测定。结果 血栓组患者的C反应蛋白（7.18±1.22）mg/L、D-二聚体水平（6.31±1.74）mg/L、低蛋白血症70.0%、狼疮性肾炎75.0%、肾功能不全70.0%、肾病综合征55.0%、肾性高血压发生率67.5%均显著高于对照组（t=2.365、2.306，χ2=4.303、3.182、2.776、2.571、2.447，P<0.05）。结论 SLE合并静脉血栓栓塞性疾病的高危因素包括C反应蛋白、D-二聚体水平升高、低蛋白血症、肾功能不全、肾性高血压、肾病综合征、狼疮性肾炎。

[关键词] SLE合并静脉血栓栓塞性疾病；高危因素；临床特点；预防

[中图分类号] R54 [文献标识码] A [文章编号] 1674-0742（2018）05（a）-0049-03

Research on High-risk Factors， Clinical Features and Prevention of SLE Combined with Venous Thromboembolic Disease

HE Jun-feng

Blood Rheumatology Department， Deyang Peoples Hospital， Deyang， Sichuan Province， 618000 China

[Abstract] Objective To research the high-risk factors， clinical features and prevention of SLE combined with venous thromboembolic disease. Methods 40 cases of patients with SLE combined with venous thromboembolic disease admitted and treated in our hospital from July 2014 to July 2017 were convenient selected， and the clinical data were reviewed， and the patients were used as the thrombus group， while 40 cases of patients with SLE without venous thromboembolic diseases were used as the control group， and the clinical data and laboratory indicators of the two groups were observed and measured. Results The incidence rates of C reactive protein， D-dimer， hypoproteinemia， lupus nephritis， renal inadequacy， nephrotic syndrome and renal hypertension in the thrombus group were respectively（7.18±1.22）mg/L，（6.31±1.74）mg/L， 70.0%， 75.0%， 70.0%， 55.0% and 67.5%， which were obviously higher than those in the control group（t=2.365， 2.306， χ2=4.303， 3.182， 2.776， 2.571， 2.447， P<0.05）. Conclusion The high-risk factors of SLE combined with venous thromboembolic disease includes the C reactive protein， D-dimer， hypoproteinemia， lupus nephritis， renal inadequacy， nephrotic syndrome and renal hypertension.

[Key words] SLE combined with venous thromboembolic disease； High-risk factor； Clinical feature； Prevention

靜脉血栓栓塞性疾病，极易造成患者死亡，尤其是在疾病后期，其属于一种慢性炎症性自身疾病[1]。近年来，很多相关医学研究报道了SLE合并动脉栓塞性疾病，如心肌梗死等，但是却很少有相关医学研究报道SLE合并静脉血栓栓塞性疾病。因此，对SLE合并静脉血栓栓塞性疾病患者的高危因素、临床特点进行探讨能够将有利的前提条件提供给临床认识该病程度的增强，从而对其进行积极有效的预防[2]。该研究分析了SLE合并静脉血栓栓塞性疾病的高危因素、临床特点及其预防措施，对该院2014年7月—2017年7月收治的40例疾病患者的临床资料进行分析，现报道如下。

1 资料与方法

1.1 一般资料

方便选取该院收治的40例SLE合并静脉血栓栓塞性疾病患者的临床资料进行回顾性分析，纳入标准：所有患者均符合SLE的诊断标准[3]；……