阿立哌唑对精神分裂症患者抑郁情绪及执行能力的影响

于海英　李海云　邓玉宏

[摘要] 目的 探讨阿立哌唑对精神分裂症患者抑郁情绪及执行能力的影响。方法 方便选择2014年12月—2015年12月该院精神分裂症患者82例，随机分成对照组（41例，给予利培酮治疗）和观察组（41例，给予阿立哌唑治疗）；通过汉密顿抑郁量表（HAMD）评价两组患者治疗前后抑郁情绪变化，通过执行功能行为评定量表成人版（BRIEF-A）评价两组患者治疗前后执行能力差异。 结果 治疗后，两组HAMD评分较治疗前降低，其中观察组（11.34±2.05）分明显低于对照组（15.46±2.77）分，差异有统计学意义（t=7.65，P<0.05）；两组BRIEF-A评分较治疗前降低，且观察组（111.51±23.21）分明显低于对照组（121.83±23.12）分，差异有统计学意义（t=2.02，P<0.05）。结论 阿立哌唑能够有效缓解精神分裂症患者心理抑郁情绪，提高患者执行能力，有利于患者康复，推广价值较高。

[关键词] 阿立哌唑；利培酮；精神分裂症；执行能力；心理情绪

[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2018）03（c）-0106-03

Effect of Aripiprazole on the Depression Emotion and Executive Capacity of Patients with Schizophrenia

YU Hai-ying1， LI Hai-yun1， DENG Yu-hong2

1.Fourth Department of Psychiatry， Shihezi Lyuzhou Hospital， Shihezi， Xinjiang， 832000 China；2.Department of Scientific Education， First Affiliated Hospital of Shihezi University， Shihezi， Xinjiang， 832000 China

[Abstract] Objective To discuss the effect of aripiprazole on the depression emotion and executive capacity of patients with schizophrenia. Methods 82 cases of patients with schizophrenia admitted and treated in our hospital from December 2014 to December 2015 were conveniently selected and randomly divided into two groups with 41 cases in each， the control group and the observation group were respectively treated with risperidone and aripiprazole， and the changes of depression emotions before and after treatment of the two groups were evaluated by the HAMD scale， and the executive capacity of the two groups was evaluated by the BRIEF-A. Results After treatment， the HAMD score of the two groups decreased compared with that before treatment， the score in the observation group was obviously lower than that in the control group，[（11.34±2.05）points vs （15.46±2.77）points]， and the difference was obvious （t=7.65，P<0.05）； the BRIEF-A score of the two groups decreased compared with that before treatment， and the score in the observation group was obviously lower than that in the control group， [（111.51±23.21）points vs （121.83±23.12）points]， and the difference was obvious（t=2.02，P<0.05）. Conclusion The aripiprazole can effectively relieve the mental depression emotions， and improve the executive capability of patients， which is conducive to the recovery of patients， and it is of higher promotion value.

[Key words] Aripiprazole； Risperidone； Schizophrenia； Executive capability； Mental emotion

精神分裂癥为精神科常见慢性精神性疾病，其病情复杂、复发率高，患者在临床上常出现知觉、思维、情感、行为等方面障碍以及精神活动不协调等[1]。近年来研究发现，精神分裂症患者的抑郁情绪与其执行能力存在较大关系[2]。阿立哌唑和利培酮均为临床上常用的抗精神疾病药物，但目前临床上关于二者对精神分裂症患者抑郁心理情绪及执行能力的影响的研究较为有限。因此，该文将讨论阿立哌唑与利培酮对该院2014年12月—2015年12月收治的82例精神分裂症患者抑郁情绪及执行能力的影响，现报道如下。

1 资料与方法

1.1 一般资料

方便选择该院收治精神分裂症患者82例为研究对象，所选患者均符合《国际疾病精神与行为障碍分类（第10版）》中精神分裂症的诊断标准[3]；排除脑器质疾病或者酒精等精神活性物质所导致精神障碍者，肝、肾等脏器功能不全者，阿立哌唑或者利培酮过敏者，无法完成该测试者及妊娠期或哺乳期妇女。……