比索洛尔治疗心绞痛69例临床疗效分析

刘方

[摘要] 目的 探讨比索洛尔治疗心绞痛的临床疗效分析，为临床用药治疗心绞痛提供科学理论依据。 方法 方便选取该院2016年4月—2017年6月在该院治疗的138例心绞痛患者为研究对象，随机分为对照组和观察组，每组69例。对照组采用美托洛尔进行治疗，观察组采用比索洛尔进行治疗，观察两组患者的治疗效果、不良反应及生活质量等情况。结果 观察组患者在应用比索洛尔后，总有效率为92.75%和76.81%，与对照组相比差异有统计学意义（χ2=12.31，P=0.032，P<0.05）；不良反应情况也好于对照组，不良反应率分别为5.19%和21.73%；患者的生存质量液得到明显的改善，经统计学分析，差异有统计学意义（P<0.05）。 结论 比索洛尔治疗心绞痛，不仅可以减少患者的痛苦，还可以减少患者心绞痛的发作次数，改善患者生活质量，值得在临床上应用推广。

[关键词] 比索洛尔；心绞痛；临床疗效分析

[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2018）04（c）-0112-03

Analysis of Clinical Curative Effect of Bisoprolol in Treatment of 69 Cases with Angina Pectoris

LIU Fang

Department of Cardiology， Heilongjiang Far East Cardiovascular and Cerebrovascular Hospital， Harbin， Heilongjiang Province， 150046 China

[Abstract] Objective To explore the clinical curative effect of Bisoprolol in treatment of 69 cases with angina pectoris thus providing scientific theoretical basis for the clinical mediation treatment of angina pectoris. Methods 138 cases of patients with angina pectoris admitted and treated in our hospital in our hospital from April 2016 to June 2017 were convenient selected as the research objects and randomly divided into two groups with 69 cases in each， the control group and the observation group were respectively treated with metoprolol and bisoprolol， and the treatment effect， adverse reactions and quality of life were observed. Results The total treatment effective rate in the observation group and in the control group was respectively 92.75% and 76.81%， and the difference was statistically significant（χ2=12.31， P=0.032， P<0.05）， and the adverse reactions were better than those in the control group， and the adverse reactions rate was respectively 5.19%， 21.73%， and the survival quality liquid was obviously improved， and the difference was statistically significant（P<0.05）. Conclusion The bisoprolol in treatment of angina pectoris can not only reduce the pains of patients， but also reduce the attack frequency of angina pectoris， and improve the quality of life， and it is worth clinical application and promotion.

[Key words]Bisoprolol； Angina pectoris； Analysis of clinical curative effect

心絞痛是由于冠状动脉供血不足，患者心肌急剧暂时缺血和缺氧所致的发作性胸痛或者胸部不适，主要表现为压榨性疼痛、前胸阵发性疼痛，该病多见于男性，一般40岁以上发作，劳累、饱食、情绪激动、阴雨天气也可引起心绞痛。目前，药物治疗是心绞痛治疗常用的方法之一，目前常用的药物有硝酸酯类药物、β受体阻断剂、钙离子阻滞剂、冠状动脉扩张剂可抗氧化剂等等。比索洛尔是β受体阻断剂，对支气管和血管平滑肌的β1受体有较高的亲和力，适合高血压、冠心病等病。该文方便选取2016年4月—2017年6月在该院治疗的心绞痛患者138例为研究对象，研究比索洛尔治疗心绞痛的临床效果，取得较好的效果，现报道如下。

1 资料与方法

1.1 一般资料

方便选取在该院治疗的心绞痛患者138例为研究对象，随机分为对照组与观察组，每组69例。其中对照组患者男40例，女29例，年龄42～71岁，平均年龄56.5岁，稳定型心绞痛31例，不稳定心绞痛38例；……