定坤丹结合激素治疗肾虚肝郁证月经过少患者的临床疗效及对子宫内膜厚度的影响

李嘉慧 欧妍

摘要 目的：探究定坤丹结合激素治疗肾虚肝郁证月经过少患者的临床疗效及对子宫内膜厚度的影响。方法：选取2011年1月至2015年5月北京中医医院顺义医院妇科门诊收治的确诊为肾虚肝郁证月经过少女性患者300例，随机分为对照组和观察组，每组150例。2组患者同时予雌孕激素周期治疗，观察组在此基础上予定坤丹治疗;连续治疗2个月经周期为1个疗程。共服2个疗程。结果：治疗后2组月经量、子宫内膜厚度、血清LH、E2及P水平与治疗前相比显著增加，行经时间显著延长（P<0.05）;且观察组变化幅度均显著大于对照组（P<0.05）;治疗后观察组总有效率为90.43%，显著高于对照组的64.57%（P<0.05）。结论：定坤丹结合激素与单纯应用激素相比治疗肾虚肝郁证月经过少患者可以获得更好的治疗效果，可以明显增加患者的月经量、行经时间、性激素水平、子宫内膜厚度。

关键词 月经过少;激素;定坤丹;肾虚肝郁证;临床疗效;子宫内膜;月经量;厚度

Clinical Efficiency of Dingkun Pellet Combined with Hormone in the Treatment of Patients with Hypomenorrhea

of Kidney Deficiency Liver Depression Type and the Influence on the Endometrium

Li Jiahui， Ou Yan

（Department of Gynecology， Beijing Traditional Chinese Medicine Hospital Shunyi Hospital， Beijing 101300， China）

Abstract Objective：To investigate the clinical efficiency of Dingkun Pellet combined with hormone in the treatment of patients with hypomenorrhea of kidney deficiency and liver depression type and the influence on the endometrium. Methods：A total of 300 patients with hypomenorrhea of kidney deficiency and liver depression type who were treated in our hospital from January 2011 to January 2015 were selected and randomly divided into control group and test group， with 150 cases in each group. Both groups received the regular estrogen and progestin hormone treatment， and the test group added Dingkun Pellet. One treatment course included 2 menorrhea circle time， and the treatment lasted 2 courses. Results：After treatment， the menorrhea blood quality， menorrhea lasting time， endometrium thickness and serum LH， E2 and P levels of the 2 groups all increased significantly （P<0.0 5or P<0.01）， and the rangeability in the test group was significant larger than the control group （P<0.01）. The total effective rate was 90.43%， which was higher than that 64.57% of control group （P<0.01）. Conclusion：The clinical efficiency of Dingkun Pellet combined with hormone in the treatment of patients with hypomenorrhea of kidney deficiency and liver depression type is better than sex hormone alone， which can outstandingly increase menorrhea blood quality， menorrhea lasting time， endometrium thickness and sex hormone levels.

Key Words Hypomenorrhea; Hormone; Dingkun Pellet; Kidney deficiency and liver depression type; Clinical efficiency; Endomembrane; Menstrual blood volume; Thickness

中圖分类号：R289.5文献标识码：Adoi：10.3969/j.issn.1673-7202.2018.03.031

月经过少是临床妇科中的常见和多发病，包括行经时间明显缩短和经量显著减少2个方面[1]。一般认为在经期内经量少于30 mL，就可以称之为月经过少。月经过少往往与女性早衰、内分泌失调、不孕等密切相关，严重影响女性健康[2]。目前西医多行激素治疗，而中医强调整体调节、辨证论治，多从调整脏腑气血人手，月经的产生是以肾为主导的，然肝肾同源，肾藏精，肝藏血，精血互生，同为月经的物质基础，故肾虚肝郁证为月经过少患者的常见证型，且中医主要主张补肾疏肝法为主要治疗原则。而我们在临床中应用定坤丹结合激素治疗肾虚肝郁证月经过少获得了满意的治疗效果，现报道如下。

1 资料与方法

1.1 一般资料

选取2011年1月至2015年5月本院妇科门诊收治的肾虚肝郁证月经过少女性患者300例，将其随机分为对照组和观察组，每组150例。……