癌因性疲乏对妇科肿瘤患者化疗期间生活质量的影响

陈君　耿红玲　秦晓辉

[摘要]目的 探讨癌因性疲乏对妇科肿瘤患者化疗期间生活质量的影响。方法 选取2014年6月～2017年6月我院收治的118例妇科恶性肿瘤化疗患者，对其进行问卷调查，分析癌因性疲乏和生活质量的相关性。结果 躯体疲乏得分最高，其次是情感疲乏、认知疲乏。患者化疗期间整体健康状况，处于较差水平。癌因性疲乏与整体健康状况呈显著负相关（P<0.05）；癌因性疲乏与生活质量各功能领域呈显著负相关（P<0.05）；癌因性疲乏与生活质量各症状领域呈显著正相关（P<0.05）；癌因性疲乏与睡眠障碍、经济状况呈显著正相关（P<0.05）。结论 妇科肿瘤患者化疗期间癌因性疲乏与生活质量存在相关性，患者癌因性疲乏越严重，生活质量越差。

[关键词]癌因性疲乏；妇科肿瘤；化疗；生活质量

[中图分类号] R473.73 [文献标识码] A [文章编号] 1674-4721（2018）7（b）-0066-03

[Abstract] Objective To investigate the effect of cancer-induced fatigue on the quality of life of the patients with gynecological cancer during chemotherapy. Methods A total of 118 patients with gynecological malignancy who were hospitalized from June 2014 to June 2017 were selected for a questionnaire survey， so as to analyze the correlation between cancer-related fatigue and quality of life. Results Physical fatigue scored was the highest， followed by emotional fatigue and cognitive fatigue. The overall health status of patients during chemotherapy was poor. There was a significant negative correlation between cancer-related fatigue and overall health （P<0.05）. There was a significant negative correlation between cancer-related fatigue and various functional areas of quality of life （P<0.05）. Cancer-related fatigue was significantly and positively correlated with various symptom areas of quality of life （P<0.05）. Cancer-related fatigue was significantly and positively correlated with sleep disorders and economic conditions （P<0.05）. Conclusion There is a correlation between cancer-induced fatigue and quality of life during chemotherapy in the patients with gynecological cancer. The more severe the cancer-induced fatigue， the worse the quality of life.

[Key words] Cancer-induced fatigue； Gynecologic cancer； Chemotherapy； Quality of life

癌因性疲乏（CRF）是由癌癥或癌症治疗引起的持续主观的乏力感，与近期体力活动不成比例[1]，严重影响患者的生活质量。妇科癌症占女性癌症发生率的18%，仅次于乳腺癌[2]。妇科癌症一旦确诊，多采用手术、化疗、放疗等综合疗法，给患者带来巨大的痛苦。国内有报道显示，妇科癌症患者癌因性疲乏的发生率为92.5%[3]。本研究对妇科肿瘤患者化疗期间的癌因性疲乏及生活质量进行调查，分析癌因性疲乏对生活质量的影响，现报道如下。

1 资料与方法

1.1 一般资料

选取2014年6月～2017年6月我院收治的118例妇科恶性肿瘤化疗患者且手术后均进行化疗。纳入标准：术后病理检查为妇科恶性肿瘤；术后进行化疗；年龄≥18岁；患者神志清楚，无精神疾病、无认知功能障碍，言语表达清楚。排除标准：同时患有其他恶性肿瘤患者。本研究遵循自愿原则，向研究对象说明研究目的，取得研究对象的知情同意，且本研究已取得医院医学伦理委员会的批准。……