复方蓝棕果片联合坦索罗辛治疗良性前列腺增生伴尿路梗阻的疗效分析

邓迦洛

[摘要] 目的 分析復方蓝棕果片联合坦索罗辛治疗良性前列腺增生伴尿路梗阻患者的临床效果。方法 方便选取2016年9月—2017年9月该院收治的78例良性前列腺增生伴尿路梗阻患者作为研究对象，采取随机数字表法将其分为参照组和实验组，每组39例。参照组给予坦索罗辛口服治疗，实验组则采用复方蓝棕果片联合坦索罗辛治疗。记录比较两组患者治疗前后的最大尿流率（Qmax）、残余尿量（PVR）、IPSS评分、QOL评分、前列腺体积变化情况，并观察比较两组患者用药期间的不良反应情况。 结果 与治疗前比较，两组患者治疗后的Qmax明显提高，PVR、IPSS评分及QOL评分均显著降低（P<0.05），实验组患者的前列腺体积由（43.63±4.79）mL缩小至（32.09±3.98）mL，明显缩小（t=7.471，P<0.05），但参照组的前列腺体积由（43.71±4.84）mL缩小至（39.68±4.61）mL，没有明显改变（P>0.05）。实验组患者治疗后的Qmax明显高于参照组，PVR、IPSS评分、QOL评分以及前列腺体积均明显低于参照组（P<0.05）。参照组和实验组不良反应发生率分别为5.13%、7.69%，两组比较差异无统计学意义（P>0.05）。 结论 良性前列腺增生伴尿路梗阻患者应用复方蓝棕果片联合坦索罗辛治疗，能提高治疗效果，减轻前列腺增生，有效改善症状，提高患者生活质量，且安全性较好。

[关键词] 复方蓝棕果片;坦索罗辛;良性前列腺增生;临床效果

[中图分类号] R697          [文献标识码] A          [文章编号] 1674-0742（2018）08（c）-0007-03

Therapeutic Effect of Compound Blue Palm Fruit Combined with Tamsulosin on Benign Prostatic Hyperplasia with Urinary Obstruction

DENG Jia-luo

Department of Urology， People's Hospital of Renshou County， Renshou， Sichuan Province， 620500 China

[Abstract] Objective To analyze the clinical effects of compound blue-flavored fruit tablets combined with tamsulosin in the treatment of benign prostatic hyperplasia with urinary tract obstruction. Methods 78 patients with benign prostatic hyperplasia with urinary tract obstruction treated in the hospital from September 2016 to September 2017 were convenient selected as study subjects. Random number table was used to divide them into control group and experimental group， with 39 cases in each group. The reference group was given oral tamsulosin， and the experimental group was treated with compound blue-and-blue fruit and tamsulosin. The maximal urinary flow rate （Qmax）， residual urine volume （PVR）， IPSS score， QOL score， and prostate volume change before and after treatment were recorded and compared between the two groups， and the adverse reactions during drug use were compared between the two groups. Results Compared with before treatment， Qmax and PVR， IPSS scores and QOL scores of the two groups were significantly lower after treatment（P<0.05）. The prostate volume in the experimental group decreased from （43.63±4.79）mL to （32.09±3.98）mL， which was significantly reduced （P<0.05）， but the prostate volume in the reference group was （43.71±4.84）mL was reduced to （39.68±4.61）mL without significant change （P>0.05）. The Qmax of the experimental group after treatment was significantly higher than that of the reference group. The PVR， IPSS score， QOL score， and prostate volume were significantly lower than the reference group （P<0.05）. The incidence of adverse reactions in the reference group and the experimental group was 5.13% and 7.69%， respectively， and there was no statistical difference between the two groups （P>0.05）. Conclusion Treatment of patients with benign prostatic hyperplasia with urinary tract obstruction with compound blue-and-blue fruit tablets combined with tamsulosin can improve the therapeutic effect， reduce the hyperplasia of the prostate， effectively improve the symptoms， improve the patient's quality of life， with good safety.

[Key words] Compound blue-palm fruit; Tamsulosin; Benign prostatic hyperplasia; Clinical effect

良性前列腺增生症（BPH）是临床常见的男性泌尿系统疾病之一，常见于老年男性。患者常表现为尿急、尿频、排尿困难等症状、还可能诱发下尿路梗阻，泌尿系统感染等，严重影响患者的性生活质量[1]。坦索洛新属于高选择性的前列腺α1受体阻断剂，能改善下尿路梗阻的现象，但是单独应用时，治疗周期长，而且研究发现坦索洛对于前列腺局限炎症并没有明显的改善作用[2]。……