血府逐瘀汤联合阿立哌唑治疗抗精神疾病药物所致闭经的精神分裂症的效果

崔晓庆 张林

【摘要】 目的：探讨抗精神疾病药物引起闭经的精神分裂症患者应用血府逐瘀汤联合阿立哌唑的治疗效果。方法：选取笔者所在医院2017年1月-2019年1月收治的88例服用抗精神病药物引起闭经的精神分裂症患者，将其随机分为观察组与对照组，各44例。对照组单独使用阿立哌唑治疗，观察组给予血府逐瘀汤联合阿立哌唑治疗，比较两组治疗效果。结果：观察组治疗总有效率为97.73%，明显高于对照组的72.73%，差异有统计学意义（P<0.05）。治疗后，两组PANSS评分均较治疗前降低（P<0.05），且观察组明显低于对照组，差异有统计学意义（P<0.05）。结论：血府逐瘀汤联合阿立哌唑应用于抗精神病药物引起的闭经精神分裂症患者治疗中，可显著改善患者精神分裂症状，治疗效果较好，值得推广。

【关键词】 血府逐瘀汤 阿立哌唑 精神分裂症 闭经 抗精神疾病药物 疗效评价

doi：10.14033/j.cnki.cfmr.2019.30.070 文献标识码 B 文章编号 1674-6805（2019）30-0-02

[Abstract] Objective： To investigate the therapeutic effect of Xuefu Zhuyu Decoction combined with Aripiprazole in schizophrenia patients with amenorrhea caused by antipsychotic drugs. Method： A total of 88 schizophrenia patients with amenorrhea caused by antipsychotic drugs in our hospital between January 2017 and January 2019 were selected and randomly divided into the observation group and the control group， with 44 cases in each group. The control group was treated with Aripiprazole alone， while the observation group was treated with Xuefu Zhuyu Decoction combined with Aripiprazole. The therapeutic effects of the two groups were compared. Result： The total effective rate of the observation group was 97.73%， which was significantly higher than 72.73% of the control group， the difference was statistically significant （P<0.05）. After treatment， PANSS score in both groups was lower than that before treatment （P<0.05）， and the observation group was significantly lower than the control group， the difference was statistically significant （P<0.05）. Conclusion： The application of Xuefu Zhuyu Decoction combined with Aripiprazole in the treatment of schizophrenia patients with amenorrhea caused by antipsychotic drugs can significantly improve the symptoms of schizophrenia， the treatment effect is good， which is worth promoting.

[Key words] Xuefu Zhuyu Decoction Aripiprazole Schizophrenia Amenorrhea Antipsychotic drugs Efficacy evaluation

First-authors address： Fuzhou Shenkang Hospital， Fuzhou 350011， China

抗精神病藥物在精神分裂症患者治疗中应用较多，长期用药有降低抑制垂体分泌催乳素的情况，增加了催乳素的分泌，进而对垂体促性腺激素及卵巢激素产生抑制，影响卵巢功能，引起闭经发生[1-2]。在抗精神病药物引起精神分裂症患者闭经治疗中，阿立哌唑比较常用，有一定的治疗效果，但疗效不理想[3]。所以，本次研究针对笔者所在医院88例抗精神病药物引起的精神分裂症闭经患者进行研究，对血府逐瘀汤与阿立哌唑联合治疗的效果进行观察，现报道如下。

1 资料与方法

1.1 一般资料

选取笔者所在医院2017年1月-2019年1月收治的88例服用抗精神病药物引起闭经的精神分裂症患者，所有患者均符合CCMD-3（中国精神障碍分类与诊断标准）中关于精神分裂症诊断标准[4];年龄17～40岁，有长期服用抗精神疾病药物史，闭经时间3个月以上。排除合并其他躯体疾病者、其他因素引起闭经者。……