雷贝拉唑及莫沙必利联合阿莫西林克拉维酸钾治疗反流性咽炎的效果观察

谢红卫 张海琼

【摘要】 目的：觀察雷贝拉唑及莫沙必利联合阿莫西林克拉维酸钾对反流性咽炎的疗效。方法：选取本院2015年1月1日-2016年12月1日收治的200例反流性咽炎患者，将其按照随机数字表法分为对照组和研究组，各100例。对照组患者采用雷贝拉唑及莫沙必利进行治疗，研究组患者采用雷贝拉唑及莫沙必利联合阿莫西林克拉维酸钾进行治疗，观察并比较两组患者的治疗效果、临床症状、咳嗽和咽部疼痛缓解情况。结果：研究组患者治疗总有效率明显高于对照组（P<0.05）。治疗前，两组患者的临床症状评分比较，差异无统计学意义（P>0.05）;治疗2、4周后，研究组患者的临床症状评分均明显低于对照组（P<0.05）。治疗后，研究组的咳嗽症状缓解率、咽部疼痛症状缓解率均高于对照组（P<0.05）。治疗后，研究组反酸、呃逆以及胸痛症状消退时间均显著短于对照组（P<0.05）。治疗后，研究组患者的复发率明显低于对照组（P<0.05）。结论：采用雷贝拉唑及莫沙必利联合阿莫西林克拉维酸钾对患者进行治疗，能够明显提高治疗效果，较快的减轻患者的临床症状，有效的缓解患者咳嗽和咽部的疼痛感，值得在临床上进一步推广应用。

【关键词】 雷贝拉唑; 莫沙必利; 阿莫西林克拉维酸钾; 反流性咽炎

【Abstract】 Objective：To observe the effect of Rabeprazole and Moxapride combined with Amoxicillin and Clavulanate Potassium on reflux pharyngitis.Method：From January 1，2015 to December 1，2016，200 patients with reflux pharyngitis in our hospital were selected and randomly divided into control group and study group，100 cases in each group.Patients in the control group were treated with Rabeprazole and Moxapride，patients in the study group were treated with Rabeprazole and Moxapride combined with Amoxicillin and Clavulanate Potassium.The therapeutic effect，clinical symptoms，cough and pharyngeal pain relief were observed and compared between the two groups.Result：The total effective rate in the study group was significantly higher than that in the control group（P<0.05）.Before treatment，there was no significant difference in clinical symptom scores between the two groups（P>0.05）;after treatment for 2 and 4 weeks，the clinical symptom scores of the patients in the study group were significantly lower than those in the control group（P<0.05）.After treatment，the cough symptom remission rate and pharyngeal pain symptom remission rate in the study group were both higher than those in the control group（P<0.05）.After treatment，the symptoms of acid reflux，hiccup and chest pain in the study group were significantly shorter than those in the control group（P<0.05）.After treatment，the recurrence rate in the study group was significantly lower than that in the control group（P<0.05）.Conclusion：The treatment of patients with Rabeprazole and Moxabelic combined with Amoxicillin and Clavulanate Potassium can significantly improve the treatment effect，rapidly reduce the clinical symptoms of patients，and effectively relieve the cough and pharyngeal pain，which is worthy of further promotion and application in clinical practice.

【Key words】 Rabeprazole; Mosapride; Amoxicillin and Clavulanate Potassium; Reflux pharyngitis

First-authors address：The Second Peoples Hospital of Pingxiang，Pingxiang 337000，China

doi：10.3969/j.issn.1674-4985.2019.11.029

反流性咽炎是一种胃中的内容物流入食管内，进而引起的咽喉肿胀以及各种并发症的疾病[1]。据相关数据显示，该种疾病能够引起食管外的症状，例如：咽喉炎、慢性咳嗽以及哮喘等并发症，该种疾病与体征关系以及耳鼻喉症状存在很大的联系[2]。反流性咽炎就是由于胃食管反流而引起的慢性咽炎。该种病症常见的症状为咽部存在异物感、声音嘶哑、吞咽出现不适感、频繁清嗓等，严重时甚至会出现反酸、胃灼热等现象，严重威胁患者的身体健康，降低患者的生活质量。在临床上，许多医生在诊断时误诊为普通咽炎，给患者的身心带来了较大的伤害。此外，对于该种疾病的常规治疗来说，治疗效果较差，出现不良反应的情况较多，安全性较差，针对性较差，患者的恢复时间较长[3]。……