李璟



【摘要】 目的:探讨右美托咪定在精神运动发育迟缓患儿MRI检查中的镇静效果。方法:选取2017年1月-2018年8月本院接诊的2~6岁精神运动发育迟缓患儿60例,将其按照数字表法分为对照组、A组、B组三组,每组20例。对照组口服10%水合氯醛(0.5 mL/kg),A组2 mcg/kg右美托咪定滴鼻,B组2.5 mcg/kg右美托咪定滴鼻,分别观察并记录三组患儿的镇静效果与不良反应发生情况。结果:A组和B组镇静成功时间均优于对照组(P<0.05),A租不良反应发生率低于B组(P<0.05)。结论:右美托咪定在精神运动发育迟缓患儿MRI检查中的镇静效果理想,患儿的接受程度高,用药时容易配合医生,成功时间短,而且产生的副作用少,给患儿带来损害更小。
【关键词】 右美托咪定; 水合氯醛; 精神运动发育迟缓; MRI
Sedative Effect of Dexmedetomidine in Children with Mental and Motor Retardation during MRI Examination/LI Jing.//Medical Innovation of China,2019,16(06):0-064
【Abstract】 Objective:To investigate the sedative effect of Dexmedetomidine in children with mental and motor retardation during MRI examination.Method:A total of 60 children aged 2 to 6 years old with mental and motor retardation were selected from January 2017 to August 2018.They were divided into the control group,A group and B group according to the number table method,20 cases in each group.The control group was given 10% Chloral Hydrate(0.5 mL/kg),A group was given 2 mcg/kg Dexmedetomidine nasal drops,and B group was given 2.5 mcg/kg Dexmedetomidine nasal drops.The sedative effect and adverse reactions of the three groups were observed and recorded.Result:The onset time of sedation in A group and B group were better than that in control group(P<0.05),and the incidence of adverse reactions in A group was lower than that in B group(P<0.05).Conclusion:Dexmedetomidine has an ideal sedative effect during MRI examination of children with mental and motor retardation,with high acceptance,easy cooperation with doctors,short onset time,less side effects and less damage to children.
【Key words】 Dexmedetomidine; Chloral Hydrate; Mental retardation; MRI
First-authors address:Dongguan City Maternal and Child Health Hospital,Dongguan 523000,China
doi:10.3969/j.issn.1674-4985.2019.06.016
MRI檢查即核磁共振检查,患儿在进行MRI检查时,需要通过镇静帮助他们保持不动至少
10 min。精神运动发育迟缓的患儿,神经系统发育不完善,自觉性较差,在检查时会对检查仪器产生恐惧感,从而会增强他们的心理防患意识[1]。目前门诊多采用口服10%水合氯醛进行镇静,患儿配合度低,门诊镇静应该选择患儿及家长容易配合的方式和安全性高的药物。右美托咪定滴鼻是一种新型的脑靶向给药方式,其是通过激活α肾上腺素受体以及与其耦联的G蛋白信号通路,具有高度的选择性,发挥类似于自然睡眠的镇静作用,对患儿的呼吸且没有明显抑制作用[2]。本研究探讨需要进行MRI检查的精神运动发育迟缓患儿使用右美托咪定滴鼻进行镇静时的安全性和有效性,现报道如下。
1 资料与方法
1.1 一般资料 选取2017年1月-2018年8月本院接诊的2~6岁由康复科医生确诊为精神运动发育迟缓患儿60例,应用随机数字表法将其随机分为对照组、A组、B组三组,每组20例。纳入……