DNA抑制基因转型修复技术在治疗生殖器疱疹中的应用

许鸣 孙淑琴 傅悦 刘虹 薛晏 王永革

【摘  要】目的：探讨DNA抑制基因转型修复技术在治疗生殖器疱疹中的临床效果。方法：选取2015年1月-2018年6月以确诊为生殖器泡疹的268例性病就诊者做为研究对象，运用该技术进行治疗，结果：1-3天，快速消症，4 -5天，激活抗体， 受损病灶得以修复，6-7天，强效免疫因子，形成终生抗体，经过长达12-18月的跟踪随访，未发现复发病例。结论： DNA抑制基因转型修复技术在治疗生殖器疱疹方面有明显的疗效，具有疗程短，见效快，安全不易复发的优势，具有明显的临床应用前景，值得推广应用。

【关健词】DNA抑制基因转型修复技术治疗;生殖器疱疹;

【中图分类号】R198      【文献标识码】A      【文章编号】1004-7484（2019）07-0292-02

Application of DNA Inhibiting Gene Transformation-based Repair Technology in Treating Herpes Progenitalis

Ming Xu¹  Shu Qin Sun²  Yong Ge Wang¹  Hong liu³  Yang Xue⁴

1. Harbin Center for Disease Control and Prevention， Harbin， 150056;2.Infectious Disease Hospital of Harbin City，Heilongjiang Province， Harbin， 150030

3.Harbin Maternity and Child Health Hospital， Harbin， 150010;4.Heilongjiang Reproductive Health Services Center ，Harbin， 150029

【Abstract】Objective： To explore the clinical effect of DNA inhibiting gene transformation-based repair technology in treating herpes progenitalis. Methods： 268 clinic sexually transmitted diseases attendants diagnosed with herpes progenitalis from January 2015 to June 2018 were selected as the research objects and then treated by using this technology. Results： The symptoms were eliminated after 1 to 3 days， the antibody was activated and the affected lesions were repaired after 4 to 5 days， and potent immune factors formed a lifelong antibody after 6 to 7 days. No recurrent cases were found during a follow-up period of 12 to 18 days. Conclusion： DNA inhibiting gene transformation-based repair technology has a distinct curative effect in treating herpes progenitalis. With a short course of treatment， fast effect， high safety and less reoccurrence， this technology has wide clinical prospect and should be promoted.

【Keywords】DNA suppressor gene transformation and repair technique; treatment; genital herpes

生殖器皰疹（genital herpes），又称阴部疱疹或疱疹二型，是由单纯疱疹病毒 （Herpes simplex virus， HSV） 感染生殖器所引起的性传播疾病^[1]，临床上主要表现为生殖器炎性病变，症状具有多样性和反复性，可引发生殖器癌变，主要由HSV-2， 部分为HSV-1^[2]感染所致。都是双链 DNA 病毒。HSV通过皮肤与皮肤或皮肤与粘膜的接触，进入生殖器基底层的上皮细胞，复制并扩散到相邻细胞，一般潜伏期约五至六天;HSV的双链 DNA 基因组的核壳体被感觉神经轴突侵入，可潜伏在人体神经结节内， 并以逆行方式运输至感觉神经根神经节，部分病毒在再次复制并扩散到邻近的神经元，五至八成的病人会有复发的机会。

由于生殖器疱疹在全球发病率较高，具有易复 发、慢性化、难根治等特点^[3]，HSV 感染除对生殖器官直接损伤外，可导致男性不育、加大生殖器肿瘤发病率，易可增加人类免疫缺陷病毒（ HIV ）感染机会，已引起医学界广泛关注。……