慢性胰腺炎合并胰管结石的诊治进展

2019-10-21 03:59:57邹宇
中国保健营养 2019年6期

邹宇

【摘  要】90%的慢性胰腺炎(chronic pancreatitis,CP)患者合并胰管结石,对于胰管结石诊治主要为内镜治疗和外科手术治疗,内镜治疗包括内镜下胰管括约肌切开取石术(endoscopic pancreatic sphincterotomy,EPS)、胰管支架引流术、胰管扩张术、主副乳头扩张术等,外科手术治疗包括胰尾切除、胰管切开+ 胰腺空肠吻合术(Duval 法)、胰尾+ 脾切除术、胰十二指肠切除术(Whipple 术),保留十二指肠的胰头切除术。综合考虑,内镜下治疗为首选方案,但对于内镜下无法处理的胰管狭窄、胰管结石等,仍需外科手术治疗。

【关键词】慢性胰腺炎;胰管结石;内镜治疗;手术治疗

【中图分类号】R657.51           【文献标识码】A       【文章编号】1004-7484(2019)06-0325-02

Diagnosis and treatment of chronic pancreatitis combined with pancreatic duct stones

Zou Yu

(Gastroenterology of Mianyang Central Hospital,Mian Yang,621000 )

【Abstract】Ninety percent of patients with chronic pancreatitis(CP) are combined with pancreatic stones. The diagnosis and treatment of pancreatic stones are mainly endoscopic treatment and surgical treatment. Endoscopic treatment includes endoscopic sphincterotomy(endoscopic sphinctorotomy, EPS), pancreatic tube stent drainage, pancreatic duct dilation, primary and secondary papillary dilation, etc.. Surgical treatment includes pancreatic tail resection, pancreatic duct incision + pancreatic empty intestinal ablation(Duval method), pancreatic tail + splenectomy, pancreatoduodenectomy(Whipple surgery), Pancreatic head resection with Duodenal preservation. Overall, endoscopic treatment is the preferred option, but surgical treatment is still required for pancreatic stenosis and pancreatic stones that can not be treated under endoscope.

【Key words】chronic pancreatitis;Pancreatic stones;Endoscopic treatment;Surgical treatment.

慢性胰腺炎(chronic pancreatitis,CP)是由于各种病因引起的胰腺组织和功能不可逆的慢性炎症改变。疼痛是其最主要的癥状,可由多种因素造成,包括胰管内和胰腺实质压力增高、胰腺缺血、胰周和腹腔神经炎症。慢性胰腺炎可伴有胰腺实质钙化、胰管结石等[1-3],其中有90%的CP患者合并胰管结石[4]。目前慢性胰腺炎合并胰管结石的治疗方式主要为内镜和外科治疗,内科内镜治疗创伤小,当内科治疗无效或出现严重并发症时可采用外科手术治疗[5]。外科手术创伤大,部分已经被迅速发展起来的内镜治疗代替,内镜治疗创伤小、恢复快,可重复性高,已基本成为慢性胰腺炎合并胰管结石的首选治疗方式,现综述如下。

1慢性胰腺炎合并胰管结石的诊断

慢性胰腺炎和胰管结石的关系较密切,胰管结石的形成和发展与慢性胰腺炎互为因果,容易形成恶性循环,最终会导致胰腺的内外分泌功能障碍。……

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