氯米芬联合定经汤加减治疗排卵障碍性不孕症的效果分析

2019-12-02 12:56莫小余
中国实用医药 2019年29期
关键词:中医学

莫小余

【摘要】 目的 探讨氯米芬联合定经汤加减治疗排卵障碍性不孕症的临床效果。方法 80例排卵障碍性不孕症患者, 按照随机数字表法分为对照组和观察组, 每组40例。对照组患者给予氯米芬治疗, 观察组患者给予氯米芬联合定经汤加减治疗。观察比较两组患者的临床疗效、排卵率、治疗前后的性激素指标[促黄体生成素(LH)、促卵泡生成素(FSH)、雌二醇(E2)]及卵泡直径。结果 治疗后, 观察组患者的治疗总有效率90.00%、排卵率95.00%均明显高于对照组的70.00%、80.00%, 差异均有统计学意义(P<0.05)。治疗后, 观察组患者的LH、FSH均明显低于对照组, E2明显高于对照组, 观察组患者的卵泡直径明显大于对照组, 差异均有统计学意义(P<0.05)。结论 氯米芬联合定经汤加减治疗可提高排卵障碍性不孕症患者的临床疗效, 纠正其性激素水平, 促使其卵泡发育及排卵, 值得临床推广。

【关键词】 排卵障碍性不孕症;氯米芬;定经汤;中医学

DOI:10.14163/j.cnki.11-5547/r.2019.29.062

【Abstract】 Objective   To discuss the clinical effect of clomiphene combined with addition and subtraction of Dingjing decoction in the treatment of anovulatory infertility. Methods   A total of 80 anovulatory infertility patients were divided into control group and observation group according to random number table method, with 40 cases in each group. Observation was made on clinical efficacy, ovulation rate, sex hormone indexes [Luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2)] before and after treatment and follicle diameter between the two groups. Results   After treatment, the total effective rate of treatment 90.00% and ovulation rate 95.00% in the observation group was obviously higher than 70.00% and 80.00% in the control group, and their difference was statistically significant (P<0.05). After treatment, the LH and FSH in the observation group was obviously lower than those in the control group, E2 was obviously higher than that in the control group, and the follicle diameter was obviously larger than that in the control group. The difference was statistically significant (P<0.05). Conclusion   Clomiphene combined with Dingjing decoction can improve the clinical efficacy of patients with anovulatory infertility, correct their sex hormone levels and promote follicular development and ovulation. It is worthy of clinical promotion.

【Key words】 Anovulatory infertility; Clomiphene; Dingjing decoction; Traditional Chinese medicine

排卵障礙性不孕症是临床常见不孕症类型, 严重影响育龄期女性的身心健康, 故临床上需要对其予以积极治疗[1-3]。氯米芬是治疗不孕症的常用药物[4], 而近年来, 中药治疗不孕症的疗效显著, 故本研究为了探讨氯米芬联合定经汤加减治疗排卵障碍性不孕症的临床效果, 选取80例排卵障碍性不孕症患者作为研究对象, 现具体报告如下。

1 资料与方法

1. 1 一般资料 选取2016年7月~2018年10月湛江市第一中医医院收治的80例排卵障碍性不孕症患者作为研究对象, 按照随机数字表法分为对照组和观察组, 每组40例。对照组患者年龄21~35岁, 平均年龄(28.05±5.49)岁;病程1~3年, 平均病程(1.52±0.54)年。观察组患者年龄22~36岁, 平均年龄(28.31±5.32)岁;病程1~3年, 平均病程(1.57±0.53)年。

两组患者的年龄及病程等一般资料比较差异均无统计学意义(P>0.05), 具有可比性。本研究已经本院医学伦理委员会审批通过, 且取得患者及其家属同意, 并签署知情同意书。

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